Developmental expression of estrogen receptor beta in the brain of prairie voles (Microtus ochrogaster)
Abstract
Here, for the first time, the expression of estrogen receptor beta (ERβ) is characterized in the brains of the highly prosocial prairie vole (Microtus ochrogaster). ERβ immunoreactivity was compared in weanlings (postnatal Day 21) and adult males and females. The results indicate several major findings. First, unlike ERα, ERβ expression is not sexually dimorphic. Second, the adult pattern of ERβ-IR is established at the time of weaning, as there were no age-dependent effects on distribution. Finally, ERβ does not appear to be as widely distributed in voles compared with rats and mice. High levels of ERβ-IR were observed in several regions/nuclei within the medial pre-optic area, ventrolateral pre-optic nuclei, and in the hypothalamus, especially in the paraventricular and supraoptic nuclei. The visualization of ERβ in prairie voles is important as the socially monogamous prairie vole functions as a human relevant model system for studying the expression of social behavior and social deficit disorders. Future studies will now be able to determine the effect of treatments on the expression and/or development of ERβ in this highly social species.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Because AVP/OT and the dopaminergic pathways they feed into are heavily influenced by sex steroids across the lifespan, their sexually dimorphic ontogeny and function may be particularly vulnerable to endocrine disruption.
“Because AVP/OT and the dopaminergic pathways they feed into are heavily influenced by sex steroids across the lifespan (50–59), it is highly plausible that their sexually dimorphic ontogeny and function may be particularly vulnerable to endocrine disruption.”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [59]
Cites
Novel Actions of Estrogen Receptor-β on Anxiety-Related Behaviors
Lund, T. D., Rovis, T., Chung, W. C. J., & Handa, R. J. (2005) · Endocrinology · doi:10.1210/en.2004-1158 · Cited by 436 · see citing works
CUSHING, B., & KRAMER, K. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.001 · Cited by 209 · see citing works
Cushing, B. S., Razzoli, M., Murphy, A. Z., Epperson, P. M., Le, W.-W., & Hoffman, G. E. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.010 · Cited by 77 · see citing works
Self-citationEndocrine Disruption of Vasopressin Systems and Related Behaviors
Patisaul, H. B. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00134 · Cited by 54 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Endocrine Disruption of Vasopressin Systems and Related Behaviors
Patisaul, H. B. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00134 · Cited by 54 · see citing works
A Neuroscientist’s Guide to the Vole
Kenkel, W. M., Gustison, M. L., & Beery, A. K. (2021) · Current Protocols · doi:10.1002/cpz1.175 · Cited by 52 · see citing works
- Authors
- Ploskonka, S. D., Eaton, J. L., Carr, M. S., Schmidt, J. V., & Cushing, B. S.
- Affiliations
- University of Akron (US)
- University of Illinois Chicago (US)
- Corresponding author
- Cushing, Bruce S.
- Venue
- Developmental Psychobiology
- Publisher
- Wiley
- Published
- 2015-09-30
- Volume
- 58
- Issue
- 2
- Pages
- 223-230
- ISSN
- 0012-1630 (ISSN-L)
- 1098-2302
- OpenAlex
- W2123349742
- Cited by
- 7
- References
- 4
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 1
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Psychobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH01992)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- estrogen receptor beta, Microtus ochrogaster, brain development, sexual dimorphism, weaning, medial preoptic area, ventrolateral preoptic nucleus, hypothalamus, paraventricular nucleus, supraoptic nucleus, social behavior, social monogamy, estrogen receptor alpha
- MeSH terms
- Age Factors, Animals, Behavior, Animal, Brain, Arvicolinae, Female, Immunohistochemistry, Male, Sex Factors, Social Behavior, Estrogen Receptor beta
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
