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Cited by 356

The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.

Visfatin in overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: a meta‐analysis and systemic review

Chang, Yu‐Hung, Chang, Dao‐Ming, Lin, Kun‐Cheng, Shin, Shyi‐Jang, Lee, Yau‐Jiunn·2011·Diabetes/Metabolism Research and Reviews

Abstract

There are controversies regarding the association of visfatin with overweight/obesity, type 2 diabetes mellitus, insulin resistance (IR), metabolic syndrome and cardiovascular disease in published articles. A meta‐analysis was performed to identify the significance of visfatin in these diseases. We searched for relevant articles in Pubmed, Scopus and SCIE. A total of 1035 articles were surveyed and 46 articles were identified, with 14 reports reporting more than one of our investigated diseases. A total of 13 (n = 644), 19 (n = 2405), 20 (n = 2249), 5 (n = 527) and 5 (n = 851) articles/(participants) were included in each meta‐analysis regarding the association of visfatin and overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases, respectively. Plasma visfatin concentrations were increased in participants diagnosed with overweight/obesity, type 2 diabetes mellitus, metabolic syndrome and cardiovascular diseases, with pooled log odds ratios of 1.164 [95% confidence interval (CI): 0.348 to 1.981, p = 0.005], 1.981 (95% CI: 1.377 to 2.584, p < 0.001), 1.094 (95% CI: 0.678 to 1.511, p < 0.001), and 2.902 (95% CI: 0.924 to 4.879, p < 0.005), respectively. The circulating visfatin level was positively associated with insulin resistance, with a Fisher's z of 0.089 (95% CI: 0.013 to 0.165, p = 0.022). No single study was found to affect the overall result of each analysis by sensitivity testing. No publication bias was found by the Egger test. Our study suggests that the use of visfatin may be promising for predicting obesity, diabetes status, insulin resistance, metabolic syndrome and cardiovascular disease. Copyright © 2011 John Wiley & Sons, Ltd.

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Metadata

Authors
Chang, Y., Chang, D., Lin, K., Shin, S., & Lee, Y.
Venue
Diabetes/Metabolism Research and Reviews
Publisher
Wiley
Published
2011-09
Volume
27
Issue
6
Pages
515-527
ISSN
  • 1520-7552 (ISSN-L)
  • 1520-7560
OpenAlex
W1975090110
Cited by
356
References
69
FWCI
15.13
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Visfatin in overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: a meta‐analysis and systemic review. https://app.cochat.ai/papers/10.1002/dmrr.1201
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Chang, Y., Chang, D., Lin, K., Shin, S., & Lee, Y. (2011). Visfatin in overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: a meta‐analysis and systemic review. Diabetes/Metabolism Research and Reviews. https://doi.org/10.1002/dmrr.1201

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