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Cited by 1,052

The DOI matches its Crossref record; 670 of the 670 references it cites were found in a registry or an index.

NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential

Open access
Xie, Na, Zhang, Lu, Gao, Wei, Huang, Canhua, Huber, Peter Ernst, Zhou, Xiaobo, Li, Changlong, Shen, Guobo, Zou, Bingwen·2020·Signal Transduction and Targeted Therapy
DOI 10.1038/s41392-020-00311-7
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Abstract

Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators to maintain physiologic processes, enabling the plastic cells to adapt to environmental changes including nutrient perturbation, genotoxic factors, circadian disorder, infection, inflammation and xenobiotics. These effects are mainly achieved by the driving effect of NAD+ on metabolic pathways as enzyme cofactors transferring hydrogen in oxidation-reduction reactions. Besides, multiple NAD+-dependent enzymes are involved in physiology either by post-synthesis chemical modification of DNA, RNA and proteins, or releasing second messenger cyclic ADP-ribose (cADPR) and NAADP+. Prolonged disequilibrium of NAD+ metabolism disturbs the physiological functions, resulting in diseases including metabolic diseases, cancer, aging and neurodegeneration disorder. In this review, we summarize recent advances in our understanding of the molecular mechanisms of NAD+-regulated physiological responses to stresses, the contribution of NAD+ deficiency to various diseases via manipulating cellular communication networks and the potential new avenues for therapeutic intervention.

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Cites

3 retracted

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Research works printed but not linked: 15

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Metadata

Authors
Xie, N., Zhang, L., Gao, W., Huang, C., Huber, P. E., Zhou, X., Li, C., Shen, G., & Zou, B.
Venue
Signal Transduction and Targeted Therapy
Publisher
Springer Science and Business Media LLC
Published
2020-10-07
Volume
5
Issue
1
Pages
227-227
ISSN
2059-3635 (ISSN-L)
DOI
10.1038/s41392-020-00311-7
OpenAlex
W3092621787
Cited by
1,052
References
670
FWCI
41.95
Type
journal article
Language
en
Open access
gold
Licence

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CoChat. (2026). Citation check: NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. https://app.cochat.ai/papers/10.1038/s41392-020-00311-7
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Xie, N., Zhang, L., Gao, W., Huang, C., Huber, P. E., Zhou, X., Li, C., Shen, G., & Zou, B. (2020). NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. Signal Transduction and Targeted Therapy. https://doi.org/10.1038/s41392-020-00311-7

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