The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Understanding proneurotrophin actions: Recent advances and challenges
Open accessAbstract
Neurotrophins are initially synthesized as larger precursors (proneurotrophins), which undergo proteolytic cleavage to yield mature forms. Although the functions of the mature neurotrophins have been well established during neural development and in the adult nervous system, roles for the proneurotrophins in developmental and injury‐induced cell death, as well as in synaptic plasticity, have only recently been appreciated. Interestingly, both mature neurotrophins and proneurotrophins utilize dual‐receptor complexes to mediate their actions. The mature neurotrophin coreceptors consist of the Trk receptor tyrosine kinases and p75 NTR, wherein Trk transduces survival and differentiative signaling, and p75 NTR modulates the affinity and selectivity of Trk activation. On the other hand, proneurotrophins engage p75 NTR and the structurally distinct coreceptor sortilin, to initiate p75 NTR‐dependent signal transduction cascade. Although the specificity of mature neurotrophins vs. proneurotrophins actions is due in part to the formation of distinct coreceptor complexes, a number of recent studies highlight how different p75 NTR‐mediated cellular actions are modulated. Here, we review emerging evidence for a novel transmembrane mechanism for ligand‐specific p75 NTR activation and several mechanisms by which p75 NTR‐dependent apoptotic and nonapoptotic responses can be selective activated. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 2010
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Cites
Trk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537 · cited 1×
“At the molecular level, mature neurotrophins interact with two distinct receptors: p75NTR and Trk (Kaplan and Miller, 2000; Huang and Reichardt, 2003; Segal, 2003; Teng and Hempstead, 2004; Reichardt, 2006).”
BackgroundNeurotrophins and their receptors: A convergence point for many signalling pathways
Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298
Protein S-nitrosylation: Purview and parameters
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Neurotrophin signal transduction in the nervous system
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Regulation of Cell Survival by Secreted Proneurotrophins
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Self-citationProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTRand Sortilin
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Self-citationSortilin is essential for proNGF-induced neuronal cell death
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Self-citationGene transfer and molecular cloning of the rat nerve growth factor receptor
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Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
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Self-citationSecreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury
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Self-citationBDNF effects on dendritic spine morphology and hippocampal function
von Bohlen und Halbach, O., & von Bohlen und Halbach, V. (2018) · Cell and Tissue Research · doi:10.1007/s00441-017-2782-x · Cited by 218
Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction
Anastasia, A., Deinhardt, K., Chao, M. V., Will, N. E., Irmady, K., Lee, F. S., Hempstead, B. L., & Bracken, C. (2013) · Nature Communications · doi:10.1038/ncomms3490 · Cited by 215
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Metadata
- Authors
- Teng, K. K., Felice, S., Kim, T., & Hempstead, B. L.
- Venue
- Developmental Neurobiology
- Publisher
- Wiley
- Published
- 2010-02-22
- Volume
- 70
- Issue
- 5
- Pages
- 350-359
- ISSN
- 1932-8451 (ISSN-L)
- 1932-846X
- OpenAlex
- W1970310239
- Cited by
- 179
- References
- 14
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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