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Cited by 334

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus

Open access
Yang, Jianmin, Harte-Hargrove, Lauren C., Siao, Chia-Jen, Marinic, Tina, Clarke, Roshelle, Ma, Qian, Jing, Deqiang, LaFrancois, John J., Bath, Kevin G., Mark, Willie, Ballon, Douglas, Lee, Francis S., Scharfman, Helen E., Hempstead, Barbara L.·2014·Cell Reports
DOI 10.1016/j.celrep.2014.03.040
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Abstract

Experience-dependent plasticity shapes postnatal development of neural circuits, but the mechanisms that refine dendritic arbors, remodel spines, and impair synaptic activity are poorly understood. Mature brain-derived neurotrophic factor (BDNF) modulates neuronal morphology and synaptic plasticity, including long-term potentiation (LTP) via TrkB activation. BDNF is initially translated as proBDNF, which binds p75(NTR). In vitro, recombinant proBDNF modulates neuronal structure and alters hippocampal long-term plasticity, but the actions of endogenously expressed proBDNF are unclear. Therefore, we generated a cleavage-resistant probdnf knockin mouse. Our results demonstrate that proBDNF negatively regulates hippocampal dendritic complexity and spine density through p75(NTR). Hippocampal slices from probdnf mice exhibit depressed synaptic transmission, impaired LTP, and enhanced long-term depression (LTD) in area CA1. These results suggest that proBDNF acts in vivo as a biologically active factor that regulates hippocampal structure, synaptic transmission, and plasticity, effects that are distinct from those of mature BDNF.

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Metadata

Authors
Yang, J., Harte-Hargrove, L. C., Siao, C.-J., Marinic, T., Clarke, R., Ma, Q., Jing, D., LaFrancois, J. J., Bath, K. G., Mark, W., Ballon, D., Lee, F. S., Scharfman, H. E., & Hempstead, B. L.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2014-05
Volume
7
Issue
3
Pages
796-806
ISSN
2211-1247 (ISSN-L)
DOI
10.1016/j.celrep.2014.03.040
OpenAlex
W2067302534
Cited by
334
References
55
FWCI
10.20
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus. https://app.cochat.ai/papers/10.1016/j.celrep.2014.03.040
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Yang, J., Harte-Hargrove, L. C., Siao, C.-J., Marinic, T., Clarke, R., Ma, Q., Jing, D., LaFrancois, J. J., Bath, K. G., Mark, W., Ballon, D., Lee, F. S., Scharfman, H. E., & Hempstead, B. L. (2014). proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus. Cell Reports. https://doi.org/10.1016/j.celrep.2014.03.040

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.