The DOI matches its Crossref record; 231 of the 232 references it cites were found in a registry or an index.
Extracellular matrix and matrix receptors in blood–brain barrier formation and stroke
Open accessAbstract
The blood–brain barrier (BBB) is formed primarily to protect the brain microenvironment from the influx of plasma components, which may disturb neuronal functions. The BBB is a functional unit that consists mainly of specialized endothelial cells (ECs) lining the cerebral blood vessels, astrocytes, and pericytes. The BBB is a dynamic structure that is altered in neurologic diseases, such as stroke. ECs and astrocytes secrete extracellular matrix (ECM) proteins to generate and maintain the basement membranes (BMs). ECM receptors, such as integrins and dystroglycan, are also expressed at the brain microvasculature and mediate the connections between cellular and matrix components in physiology and disease. ECM proteins and receptors elicit diverse molecular signals that allow cell adaptation to environmental changes and regulate growth and cell motility. The composition of the ECM is altered upon BBB disruption and directly affects the progression of neurologic disease. The purpose of this review is to discuss the dynamic changes of ECM composition and integrin receptor expression that control BBB functions in physiology and pathology. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 71: 1018‐1039, 2011
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“Integrins mediate cell signaling by activating ECM ligands, growth factors, and growth factor receptors, which regulates multiple endothelial cell functions including survival, migration, differentiation, adhesion, and polarity (35).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [35]
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Cites
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Astrocyte-endothelial interactions at the blood-brain barrier
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Astrocytes: Biology and pathology
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Pericytes regulate the blood–brain barrier
Armulik, A., Genové, G., Mäe, M., Nisancioglu, M. H., Wallgard, E., Niaudet, C., He, L., Norlin, J., Lindblom, P., Strittmatter, K., et al. (2010) · Nature · doi:10.1038/nature09522 · Cited by 2,843
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Development, maintenance and disruption of the blood-brain barrier
Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3407 · Cited by 2,452
Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,312
Establishment and Dysfunction of the Blood-Brain Barrier
Zhao, Z., Nelson, A. R., Betsholtz, C., & Zlokovic, B. V. (2015) · Cell · doi:10.1016/j.cell.2015.10.067 · Cited by 1,670
Fibrinogen as a key regulator of inflammation in disease
Davalos, D., & Akassoglou, K. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0290-8 · Cited by 943
Self-citationFunctional morphology of the blood–brain barrier in health and disease
Liebner, S., Dijkhuizen, R. M., Reiss, Y., Plate, K. H., Agalliu, D., & Constantin, G. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1815-1 · Cited by 872
Metadata
- Authors
- Baeten, K. M., & Akassoglou, K.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Akassoglou, Katerina
- Venue
- Developmental Neurobiology
- Publisher
- Wiley
- Published
- 2011-10-11
- Volume
- 71
- Issue
- 11
- Pages
- 1018-1039
- ISSN
- 1932-8451 (ISSN-L)
- 1932-846X
- PMC
- PMC3482610
- OpenAlex
- W2067935721
- Cited by
- 397
- References
- 232
- Citations by year
- 2026: 8 · 2025: 27 · 2024: 32 · 2023: 48 · 2022: 38 · 2021: 44 · 2020: 39 · 2019: 32 · 2018: 38 · 2017: 22 · 2016: 20 · 2015: 11 · 2014: 14 · 2013: 13 · 2012: 7
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Developmental Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS066361, R01NS052189, R01NS051470)
- National Center for Research Resources (P41RR004050)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- blood-brain barrier, extracellular matrix, integrins, dystroglycan, basement membrane, endothelial cells, astrocytes, pericytes, stroke, blood-brain barrier disruption, ECM receptors, cell motility, neurovascular unit
- MeSH terms
- Animals, Blood-Brain Barrier, Brain, Humans, Microcirculation, Receptors, Cell Surface, Extracellular Matrix Proteins, Stroke
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