Cerebellar microglia are dynamically unique and survey Purkinje neurons in vivo
Open accessAbstract
Microglia are the innate immune cells of the central nervous system and are also important participants in normal development and synaptic plasticity. Here, we demonstrate that the microglia of the mouse cerebellum represent a unique population compared to cortical microglia. Microglia are more sparsely distributed within the cerebellum and have a markedly less ramified morphology compared to their cortical counterparts. Using time‐lapse in vivo imaging, we found that these differences in distribution and morphology ultimately lead to decreased parenchymal surveillance by cerebellar microglia. We also observed a novel form of somal motility in cerebellar microglia in vivo , which has not been described in cortical populations. We captured microglial interactions with Purkinje neurons in vivo . Cerebellar microglia interact dynamically with both the dendritic arbors and somas of Purkinje neurons. These findings suggest that cerebellar microglia are physiologically distinct from cortical populations and that these differences may ultimately alter how they could contribute to plasticity and disease processes in the cerebellum. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 627–644, 2018
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Clearance activity of cerebellar microglia is further supported by recent live imaging data showing significantly decreased parenchymal surveillance activity of cerebellar microglia compared to forebrain microglia in vivo.
“The clearance activity of cbMg is further supported by recent live imaging data from adult mice showing significantly decreased parenchymal surveillance activity of cbMg as compared to forebrain microglia in vivo40.”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [40]
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- Authors
- Stowell, R. D., Wong, E. L., Batchelor, H. N., Mendes, M. S., Lamantia, C. E., Whitelaw, B. S., & Majewska, A. K.
- Affiliations
- University of Rochester Medicine (US)
- Corresponding author
- Majewska, Ania K.
- Venue
- Developmental Neurobiology
- Publisher
- Wiley
- Published
- 2018-01-18
- Volume
- 78
- Issue
- 6
- Pages
- 627-644
- ISSN
- 1932-8451 (ISSN-L)
- 1932-846X
- PMC
- PMC6544048
- OpenAlex
- W2779405266
- Cited by
- 124
- References
- 37
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 22 · 2023: 13 · 2022: 16 · 2021: 18 · 2020: 7 · 2019: 17 · 2018: 6
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Developmental Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA027111)
- National Eye Institute (R01EY019277)
- National Institute of Neurological Disorders and Stroke (R21NS099973, F99NS108486)
- National Institute of Environmental Health Sciences (P30ES001247)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- Purkinje cells, microglial morphology, microglial ramification, dendritic branching, cerebellum, synaptic plasticity
- MeSH terms
- Animals, Cell Communication, Cell Count, Cell Movement, Cerebellum, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Visual Cortex, Microglia
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