The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos
Abstract
Abnormalities in valvuloseptal development significantly contribute to congenital heart defects, yet the underlying causes are complex and poorly understood. Early cardiac regulatory genes are differentially expressed during valvuloseptal development, consistent with novel functions during heart chamber formation in chicken and mouse embryos. Distinct valve cell lineages were identified in the leaflets, chordae tendineae, and myotendinous junctions with the papillary muscles based on restricted expression of extracellular matrix molecules. Specific cell types within these structures demonstrate characteristics of chondrogenesis and tendon development, identified by scleraxis, type II collagen, and tenascin expression. In chicken embryos, valve remodeling and maturation accompanies a decrease in mitotic index indicated by reduced bromodeoxyuridine incorporation. Analysis of Tie2‐cre × ROSA26R mice demonstrates that mature valve structures, including the atrioventricular and outflow tract semilunar valve leaflets, chordae tendineae, and the fibrous continuity that connects the septal leaflets of mitral and tricuspid valves, arise from endothelial cells of the endocardial cushions. Together, these studies provide novel insights into the origins and cell lineage diversity of mature valve structures in the developing vertebrate heart. Developmental Dynamics 230:239–250, 2004. © 2004 Wiley‐Liss, Inc.
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Generalized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 4,859
Congenital Heart Disease Caused by Mutations in the Transcription Factor NKX2-5
Schott, J.-J., Benson, D. W., Basson, C. T., Pease, W., Silberbach, G. M., Moak, J. P., Maron, B. J., Seidman, C. E., & Seidman, J. G. (1998) · Science · doi:10.1126/science.281.5373.108 · Cited by 1,308
Tie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo
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GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
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Fate of the mammalian cardiac neural crest
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Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome
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Cited by
Cardiac Fibrosis: The Fibroblast Awakens
Travers, J. G., Kamal, F. A., Robbins, J., Yutzey, K. E., & Blaxall, B. C. (2016) · Circulation Research · doi:10.1161/circresaha.115.306565 · Cited by 1,596
Self-citationResident fibroblast lineages mediate pressure overload–induced cardiac fibrosis
Moore-Morris, T., Guimarães-Camboa, N., Banerjee, I., Zambon, A. C., Kisseleva, T., Velayoudon, A., Stallcup, W. B., Gu, Y., Dalton, N. D., Cedenilla, M., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74783 · Cited by 630
Heart Valve Structure and Function in Development and Disease
Hinton, R. B., & Yutzey, K. E. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142145 · Cited by 498
Self-citationExtracellular Matrix Remodeling and Organization in Developing and Diseased Aortic Valves
Hinton, R. B., Lincoln, J., Deutsch, G. H., Osinska, H., Manning, P. B., Benson, D. W., & Yutzey, K. E. (2006) · Circulation Research · doi:10.1161/01.res.0000224114.65109.4e · Cited by 448
Self-citationHeart Valve Development: Regulatory Networks in Development and Disease
Combs, M. D., & Yutzey, K. E. (2009) · Circulation Research · doi:10.1161/circresaha.109.201566 · Cited by 455
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Metadata
- Authors
- Lincoln, J., Alfieri, C. M., & Yutzey, K. E.
- Venue
- Developmental Dynamics
- Publisher
- Wiley
- Published
- 2004-04-22
- Volume
- 230
- Issue
- 2
- Pages
- 239-250
- ISSN
- 1058-8388 (ISSN-L)
- 1097-0177
- OpenAlex
- W2005893713
- Cited by
- 271
- References
- 69
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- closed
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