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Cited by 72Congenital heart defects researchCongenital Heart Disease StudiesCardiac Valve Diseases and Treatments

Hemodynamic patterning of the avian atrioventricular valve

Open access
Yalcin, Huseyin C., Shekhar, Akshay, McQuinn, Tim C., Butcher, Jonathan T.·2011·Developmental Dynamics
DOI 10.1002/dvdy.22512PMC PMC3298748
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Abstract

In this study, we develop an innovative approach to rigorously quantify the evolving hemodynamic environment of the atrioventricular (AV) canal of avian embryos. Ultrasound generated velocity profiles were imported into Micro‐Computed Tomography generated anatomically precise cardiac geometries between Hamburger‐Hamilton (HH) stages 17 and 30. Computational fluid dynamic simulations were then conducted and iterated until results mimicked in vivo observations. Blood flow in tubular hearts (HH17) was laminar with parallel streamlines, but strong vortices developed simultaneous with expansion of the cushions and septal walls. For all investigated stages, highest wall shear stresses (WSS) are localized to AV canal valve–forming regions. Peak WSS increased from 19.34 dynes/cm 2 at HH17 to 287.18 dynes/cm 2 at HH30, but spatiotemporally averaged WSS became 3.62 dynes/cm 2 for HH17 to 9.11 dynes/cm 2 for HH30. Hemodynamic changes often preceded and correlated with morphological changes. These results establish a quantitative baseline supporting future hemodynamic analyses and interpretations. Developmental Dynamics, 2011. © 2010 Wiley‐Liss, Inc.

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  • Histology confirms the presence of an EMP hybrid cell state on the flow-side of the cushions where the hemodynamic load is highest.

    “Histology confirms the presence of an EMP hybrid cell state on the flow-side of the cushions where the hemodynamic load is highest50.”

    From Cell diversity and plasticity during atrioventricular heart valve EMTs (2023) · cites this paper as [50]

    The HH27 and HH30 Simulations results report higher wall shear stress on the inflow surfaces of the cushions than on their outflow surfaces. The paper does not report histological confirmation of an EMP hybrid cell state on those surfaces; its Discussion only suggests a possible relationship between higher shear stress and EMT. (LLM, conf=0.88)

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Authors
Yalcin, H. C., Shekhar, A., McQuinn, T. C., & Butcher, J. T.
Affiliations
  • Doğuş University (TR)
  • Cornell University (US)
  • University of Washington (US)
Corresponding author
Butcher, Jonathan T.
ORCID
Venue
Developmental Dynamics
Publisher
Wiley
Published
2010-12-22
Volume
240
Issue
1
Pages
23-35
ISSN
  • 1058-8388 (ISSN-L)
  • 1097-0177
DOI
10.1002/dvdy.22512
PMC
PMC3298748
OpenAlex
W2154565413
Cited by
72
References
1
Citations by year
2026: 4 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 7 · 2015: 1 · 2014: 7 · 2013: 5 · 2012: 8
FWCI
2.09
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Developmental Dynamics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Dogus University Institutional Repository (Dogus University) (submittedVersion, cc-by-nc-nd)
Funders
  • American Heart Association
  • National Heart, Lung, and Blood Institute (HL0077, R01HL110328, HL033756, R21HL083975, HL083975, R01HL033756)
  • National Center for Research Resources (RR016434, P20RR016434)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
Keywords
atrioventricular valves, avian embryo, hemodynamics, wall shear stress, cardiac cushions, Hamburger-Hamilton stages, computational fluid dynamics, micro-computed tomography, heart development, vortices, cardiac morphogenesis
MeSH terms
Animals, Birds, Blood Pressure, Chick Embryo, Computer Simulation, Coronary Circulation, Diastole, Heart Valves, Hemodynamics, Image Processing, Computer-Assisted, Ultrasonography, Body Patterning, Validation Studies as Topic, X-Ray Microtomography

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