Cited by 173Cellular Mechanics and InteractionsCongenital heart defects researchDevelopmental Biology and Gene Regulation

The Effects of Hemodynamic Force on Embryonic Development

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CULVER, JAMES C., DICKINSON, MARY E.·2010·Microcirculation

Abstract

Blood vessels have long been known to respond to hemodynamic force, and several mechanotransduction pathways have been identified. However, only recently have we begun to understand the effects of hemodynamic force on embryonic development. In this review, we will discuss specific examples illustrating the role of hemodynamic force during the development of the embryo, with particular focus on the development of the vascular system and the morphogenesis of the heart. We will also discuss the important functions served by mechanotransduction and hemodynamic force during placentation, as well as in regulating the maintenance and division of embryonic, hematopoietic, neural, and mesenchymal stem cells. Pathological misregulation of mechanosensitive pathways during pregnancy and embryonic development may contribute to the occurrence of cardiovascular birth defects, as well as to a variety of other diseases, including preeclampsia. Thus, there is a need for future studies focusing on better understanding the physiological effects of hemodynamic force during embryonic development and their role in the pathogenesis of disease.

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Crossref · 10.1111/j.1549-8719.2010.00025.x

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  • Cells in the common ventricle and outflow tract of the embryonic heart are sensitive to wall and shear forces, and increases in these forces can lead to heart defects.

    “Cells in the common ventricle and the outflow tract of the embryonic heart are sensitive to wall and shear forces (342, 442), and increases in these forces can lead to heart defects (135, 260, 379).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [135]

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  1. [41]Harvey RP Rosenthal N 1999 Heart development Academic Press San Diego

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Authors
CULVER, J. C., & DICKINSON, M. E.
Affiliations
Baylor College of Medicine (US)
Venue
Microcirculation
Publisher
Wiley
Published
2010-04
Volume
17
Issue
3
Pages
164-178
ISSN
  • 1073-9688 (ISSN-L)
  • 1549-8719
OpenAlex
W1995762323
Cited by
173
References
157
Citations by year
2026: 4 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 13 · 2020: 8 · 2019: 13 · 2018: 13 · 2017: 14 · 2016: 13 · 2015: 9 · 2014: 14 · 2013: 11 · 2012: 16
FWCI
1.11
Type
journal article
Language
en
Open access
Locations
  • Microcirculation (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R01HL096360, HL077187, R01HL077187)
  • National Institute of Biomedical Imaging and Bioengineering (EB 005173, EB-007076, R01EB005173, P20EB007076)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
hemodynamic forces, embryonic development, mechanotransduction, vascular development, cardiac morphogenesis, placenta, stem cell maintenance, hematopoietic stem cells, neural stem cells, mesenchymal stem cells, preeclampsia, pregnancy
MeSH terms
Animals, Aorta, Thoracic, Blood Vessels, Female, Fetal Heart, Hematopoiesis, Hemodynamics, Humans, Models, Cardiovascular, Embryo Implantation, Placenta, Placentation, Pregnancy, Signal Transduction, Mechanotransduction, Cellular, Endothelial Cells, Embryonic Development, Embryonic Stem Cells

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