Dopaminergic activity and altered reward modulation in anorexia nervosa-insight from multimodal imaging
Open accessAbstract
Objective: Individuals with anorexia nervosa (AN) have anxious and inhibited temperaments with high concern for consequences. Studies using either positron emission tomography (PET) or functional magnetic resonance imaging (fMRI) suggest involvement of the middle and dorsal caudate (DC) in individuals recovered (REC) from AN. For example, dopamine (DA) D2/D3 receptor binding in the middle caudate and DC was associated with anxiety and harm avoidance, and blood‐oxygen‐level‐dependent (BOLD) response in the DC was positively related to trait anxiety. It has not been shown yet whether BOLD response in individuals REC from AN was related to DA function. Methods: Post‐hoc correlation analyses between the PET and fMRI studies by correlating D2/D3 binding in striatal regions and BOLD signal in the anteroventral striatum (AVS) and DC for wins and losses respectively in 12 individuals REC from AN. Results: Individuals REC from AN with the greatest BOLD response in the DC in a monetary choice task had higher middle caudate D2/D3 binding, and greater anxiety and/or harm avoidance. Discussion: Though preliminary, these findings suggest that increased dorsal striatal D2/D3 binding is associated with enhanced cognitive response to feedback, potentially related to anxious anticipation of consequences. © 2016 Wiley Periodicals, Inc.(Int J Eat Disord 2017; 50:593–596)
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Dorsal caudate dysfunction is associated with AN in monetary choice and food-cue processing tasks.
“Dorsal caudate dysfunction is also associated with AN patients in a number of tasks, including a monetary choice task (Bischoff-Grethe et al., 2013; Bailer et al., 2016), and food-cue processing (Sanders et al., 2015).”
From Cortico-striatal-thalamic loop circuits of the salience network: A central pathway in psychiatric disease and treatment (2016) · cites this paper as Bailer et al., 2016
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- Authors
- Bailer, U. F., Price, J. C., Meltzer, C. C., Wagner, A., Mathis, C. A., Gamst, A., & Kaye, W. H.
- Affiliations
- University of California San Diego (US)
- University of Pittsburgh (US)
- Emory University (US)
- Corresponding author
- Bailer, Ursula F.
- Venue
- International Journal of Eating Disorders
- Publisher
- Wiley
- Published
- 2016-10-18
- Volume
- 50
- Issue
- 5
- Pages
- 593-596
- ISSN
- 0276-3478 (ISSN-L)
- 1098-108X
- PMC
- PMC5395366
- OpenAlex
- W2533371470
- Cited by
- 33
- References
- 18
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 4 · 2016: 2
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International Journal of Eating Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (MH046001, MH04298, K05‐MH01894, MH092793)
- Austrian Science Fund
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- anorexia nervosa, dopamine D2/D3 receptors, dorsal caudate, reward processing, trait anxiety, harm avoidance, recovery from anorexia nervosa, BOLD signal
- MeSH terms
- Adult, Anorexia Nervosa, Dopamine, Female, Humans, Male, Reward, Receptors, Dopamine D2, Multimodal Imaging
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