Linking nucleus accumbens dopamine and blood oxygenation
Abstract
Rationale Animal research suggests that anticipation of reward can elicit dopamine release in the nucleus accumbens (NAcc). Human functional magnetic resonance imaging (FMRI) research further suggests that reward anticipation can increase local blood oxygen level dependent (BOLD) signal in the NAcc. However, the physiological relationship between dopamine release and BOLD signal increases in the NAcc has not yet been established.Objectives This review considers pharmacological MRI (phMRI) evidence for a directional relationship between NAcc dopamine release and BOLD signal, as well as implications for human psychopathological symptoms.Results Accumulating phMRI evidence supports a simple model in which NAcc dopamine release activates postsynaptic D1 receptors, which changes postsynaptic membrane potential, eventually increasing local BOLD signal. This continuing influence can change on a second-to-second basis.Conclusions Dopamine release in the NAcc appears to increase local BOLD signal via agonism of postsynaptic D1 receptors. Such a physiological mechanism implies that FMRI may be used to track symptoms related to NAcc dopaminergic dysregulation in psychiatric disorders including schizophrenia and attention deficit/hyperactivity disorder.
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Phasic dopamine release is captured as an increase in the BOLD signal in fMRI studies.
“which is captured as an increase in the functional magnetic resonance imaging (BOLD) signal (or activation) in fMRI studies.11–13”
From Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder (2012) · cites this paper as [13]
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- Authors
- Knutson, B., & Gibbs, S. E. B.
- Affiliations
- Stanford University (US)
- University of California, Berkeley (US)
- Corresponding author
- Knutson, Brian
- ORCID
- Knutson, Brian
- Venue
- Psychopharmacology
- Published
- 2007-02-06
- Volume
- 191
- Issue
- 3
- Pages
- 813-822
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2148902913
- Cited by
- 337
- References
- 68
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 4 · 2023: 22 · 2022: 6 · 2021: 11 · 2020: 10 · 2019: 18 · 2018: 24 · 2017: 14 · 2016: 23 · 2015: 20 · 2014: 24 · 2013: 20 · 2012: 15
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (R03DA020615, DA020615-01)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- nucleus accumbens, dopamine release, BOLD signal, pharmacological MRI, dopamine D1 receptor, reward anticipation, schizophrenia, attention deficit hyperactivity disorder, dopaminergic dysfunction
- MeSH terms
- Animals, Attention Deficit Disorder with Hyperactivity, Brain Mapping, Cerebrovascular Circulation, Cues, Dopamine, Humans, Magnetic Resonance Imaging, Synaptic Transmission, Nucleus Accumbens, Oxygen, Reward, Schizophrenia, Dopamine Agents, Receptors, Dopamine D1
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