The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Detection of Viral SARS-CoV-2 Genomes and Histopathological Changes in Endomyocardial Biopsies
Open accessAbstract
Aims: Since December 2019, the novel coronavirus SARS-CoV-2 has spread rapidly throughout China and keeps the world in suspense. Cardiovascular complications with myocarditis and embolism due to COVID-19 have been reported. SARS-CoV-2 genome detection in the heart muscle has not been demonstrated so far, and the underlying pathophysiological mechanisms remain to be investigated. Methods and results: Endomyocardial biopsies (EMBs) of 104 patients (mean age: 57.90 ± 16.37 years; left ventricular ejection fraction: 33.7 ± 14.6%, sex: n = 79 male/25 female) with suspected myocarditis or unexplained heart failure were analysed. EMB analysis included histology, immunohistochemistry, and detection of SARS-CoV-2 genomes by real-time reverse transcription polymerase chain reaction in the IKDT Berlin, Germany. Among 104 EMBs investigated, five were confirmed with SARS-CoV-2 infected by reverse real-time transcriptase polymerase chain reaction. We describe patients of different history of symptoms and time duration. Additionally, we investigated histopathological changes in myocardial tissue showing that the inflammatory process in EMBs seemed to permeate vascular wall leading to small arterial obliteration and damage. Conclusions: This is the first report that established the evidence of SARS-CoV-2 genomes detection in EMBs. In these patients, myocardial injury ischaemia may play a role, which could explain the ubiquitous troponin increases. EMB-based identification of the cause of myocardial injury may contribute to explain the different evolution of complicated SARS-CoV-2-infection and to design future specific and personalized treatment strategies.
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Cites
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263
Endothelial cell infection and endotheliitis in COVID-19
Varga, Z., Flammer, A. J., Steiger, P., Haberecker, M., Andermatt, R., Zinkernagel, A. S., Mehra, M. R., Schuepbach, R. A., Ruschitzka, F., & Moch, H. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30937-5 · Cited by 6,358
COVID-19 and the cardiovascular system
Zheng, Y.-Y., Ma, Y.-T., Zhang, J.-Y., & Xie, X. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0360-5 · Cited by 2,970
Chen, L., Li, X., Chen, M., Feng, Y., & Xiong, C. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa078 · Cited by 1,163 · cited 1×
“ACE-2 expression might act as target cells for SARS-CoV-2 while pericyte injury can result in endothelial cell dysfunction.(20,22) If SARS CoV-2 can replicate in these target”
BackgroundMyocarditis: The Dallas criteria
Thomas Aretz, H. (1987) · Human Pathology · doi:10.1016/s0046-8177(87)80363-5 · Cited by 809
Attwell, D., Mishra, A., Hall, C. N., O’Farrell, F. M., & Dalkara, T. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15610340 · Cited by 648
Cited by
Association of Cardiac Infection With SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases
Lindner, D., Fitzek, A., Bräuninger, H., Aleshcheva, G., Edler, C., Meissner, K., Scherschel, K., Kirchhof, P., Escher, F., Schultheiss, H.-P., et al. (2020) · JAMA Cardiology · doi:10.1001/jamacardio.2020.3551 · Cited by 827
Self-citationPredictors of COVID‐19 severity: A literature review
Gallo Marin, B., Aghagoli, G., Lavine, K., Yang, L., Siff, E. J., Chiang, S. S., Salazar‐Mather, T. P., Dumenco, L., Savaria, M. C., Aung, S. N., et al. (2021) · Reviews in Medical Virology · doi:10.1002/rmv.2146 · Cited by 819
SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes
Bojkova, D., Wagner, J. U. G., Shumliakivska, M., Aslan, G. S., Saleem, U., Hansen, A., Luxán, G., Günther, S., Pham, M. D., Krishnan, J., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa267 · Cited by 257
Viral Myocarditis—From Pathophysiology to Treatment
Schultheiss, H.-P., Baumeier, C., Aleshcheva, G., Bock, C.-T., & Escher, F. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10225240 · Cited by 75
Self-citationAbdi, A., AlOtaiby, S., Badarin, F. A., Khraibi, A., Hamdan, H., & Nader, M. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112518 · Cited by 47
Metadata
- Authors
- Escher, F., Pietsch, H., Aleshcheva, G., Bock, T., Baumeier, C., Elsaesser, A., Wenzel, P., Hamm, C., Westenfeld, R., Schultheiss*, M., Gross, U., Morawietz, L., & Schultheiss, H.-P.
- Venue
- ESC Heart Failure
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-06-12
- Volume
- 7
- Issue
- 5
- Pages
- 2440-2447
- ISSN
- 2055-5822 (ISSN-L)
- OpenAlex
- W3034667454
- Cited by
- 239
- References
- 6
- FWCI
- 30.72
- Type
- journal article
- Language
- en
- Open access
- gold
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- Escher, F., Pietsch, H., Aleshcheva, G., Bock, T., Baumeier, C., Elsaesser, A., Wenzel, P., Hamm, C., Westenfeld, R., Schultheiss*, M., Gross, U., Morawietz, L., & Schultheiss, H.-P. (2020). Detection of Viral SARS-CoV-2 Genomes and Histopathological Changes in Endomyocardial Biopsies. ESC Heart Failure. https://doi.org/10.1002/ehf2.12805
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