The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2
Abstract
The site of action of the immunosuppressive drug cyclosporin A in in vitro cytotoxic allograft responses has been localized. General cytotoxic effects of the drug on proliferating T cells became apparent at concentrations of 500–1000 ng/ml, while selective effects were observed at concentrations of 10–100 ng/ml. The selective effects included a blockade of interleukin 2 release from activated T helper cells on the one hand and inhibition of interleukin 1 release from splenic adherent cells on the other. While cyclosporin A did not interfere with the intracellular events required for the activation and subsequent clonal expansion of alloreactive T cells, the lack of interleukin 1 and interleukin 2 induced by cyclosporin A results in an inability of T responder cells to mount cytotoxic allograft responses in vitro.
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Citations
Cites
A rapid method for the isolation of functional thymus‐derived murine lymphocytes
Julius, M. H., Simpson, E., & Herzenberg, L. A. (1973) · European Journal of Immunology · doi:10.1002/eji.1830031011 · Cited by 4,147
Long term culture of tumour-specific cytotoxic T cells
GILLIS, S., & SMITH, K. A. (1977) · Nature · doi:10.1038/268154a0 · Cited by 1,386
Effects of the new anti-lymphocytic peptide cyclosporin A in animals.
Borel, J. F., Feurer, C., Magnée, C., & Stähelin, H. (1977) · PubMed Central · Cited by 707
The functional relationship of the interleukins.
Smith, K. A., Lachman, L. B., Oppenheim, J. J., & Favata, M. F. (1980) · The Journal of experimental medicine · doi:10.1084/jem.151.6.1551 · Cited by 653
Two distinct factors are required for induction of T-cell growth
Larsson‐Sciard, E., Iscove, N. N., & Coutinho, A. (1980) · Nature · doi:10.1038/283664a0 · Cited by 410
Larsson, E. L. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.124.6.2828 · Cited by 343
Wagner, H., & Röllinghoff, M. (1978) · The Journal of experimental medicine · doi:10.1084/jem.148.6.1523 · Cited by 327
Self-citationStudies on the Mechanism of Action of Cyclosporin A
Wiesinger, D., & Borel, J. F. (1980) · Immunobiology · doi:10.1016/s0171-2985(80)80078-7 · Cited by 166
Cited by
KINO, T., HATANAKA, H., HASHIMOTO, M., NISHIYAMA, M., GOTO, T., OKUHARA, M., KOHSAKA, M., AOKI, H., & IMANAKA, H. (1987) · The Journal of Antibiotics · doi:10.7164/antibiotics.40.1249 · Cited by 1,241
There is more than one interleukin 1
Oppenheim, J. J., Kovacs, E. J., Matsushima, K., & Durum, S. K. (1986) · Immunology Today · doi:10.1016/0167-5699(86)90124-6 · Cited by 1,203
Miethke, T., Wahl, C., Heeg, K., Echtenacher, B., Krammer, P. H., & Wagner, H. (1992) · The Journal of experimental medicine · doi:10.1084/jem.175.1.91 · Cited by 574
Self-citationCyclosporine Improves Psoriasis in a Double-blind Study
Ellis, C. N. (1986) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1986.03380220076026 · Cited by 558
Induction of Interleukin 2 Messenger RNA Inhibited by Cyclosporin A
Elliott, J. F., Lin, Y., Mizel, S. B., Bleackley, R. C., Harnish, D. G., & Paetkau, V. (1984) · Science · doi:10.1126/science.6334364 · Cited by 395
Metadata
- Authors
- Bunjes, D., Hardt, C., Röllinghoff, M., & Wagner, H.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1981-01
- Volume
- 11
- Issue
- 8
- Pages
- 657-661
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W1997411530
- Cited by
- 629
- References
- 8
- FWCI
- 14.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bunjes, D., Hardt, C., Röllinghoff, M., & Wagner, H. (1981). Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2. European Journal of Immunology. https://doi.org/10.1002/eji.1830110812
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
