The DOI matches its Crossref record.
The functional relationship of the interleukins.
Open accessAbstract
The mechanism of the lymphoproliferative effect of the macrophage product lymphocyte-activating factor [LAF(IL1] appears to be mediated by the stimulation of the release of T cell growth factor [TCGF(IL2)] by T cells. The magnitude of the resultant T cell proliferative clonal expansion is thus dependent upon the quantity of both LAF(IL1) and TCGF(IL2) induced by antigen or lectin stimulation. These observations, coupled with the ability to measure the production and actions of these hormone-like lymphokines, should allow for increased insight into the mode of action of immunoenhancing and immunosuppressive agents, as well as for new therapeutic approaches to disease states involving T lymphocytes.
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Citations
Cited by
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
Macrophages and Polymorphonuclear Neutrophils in Lung Defense and Injury
Sibille, Y., & Reynolds, H. Y. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.2.471 · Cited by 1,083
Interleukin 1 of the central nervous system is produced by ameboid microglia.
Giulian, D., Baker, T. J., Shih, L. C., & Lachman, L. B. (1986) · The Journal of experimental medicine · doi:10.1084/jem.164.2.594 · Cited by 859
Self-citationPacifici, R., Brown, C., Puscheck, E., Friedrich, E., Slatopolsky, E., Maggio, D., McCracken, R., & Avioli, L. V. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.12.5134 · Cited by 555
Murray, H. W., Rubin, B. Y., Masur, H., & Roberts, R. B. (1984) · New England Journal of Medicine · doi:10.1056/nejm198404053101404 · Cited by 513
Metadata
- Authors
- Smith, K. A., Lachman, L. B., Oppenheim, J. J., & Favata, M. F.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1980-06-01
- Volume
- 151
- Issue
- 6
- Pages
- 1551-1556
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2144291634
- Cited by
- 653
- References
- 0
- FWCI
- 21.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The functional relationship of the interleukins. https://app.cochat.ai/papers/10.1084/jem.151.6.1551
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- Smith, K. A., Lachman, L. B., Oppenheim, J. J., & Favata, M. F. (1980). The functional relationship of the interleukins. The Journal of experimental medicine. https://doi.org/10.1084/jem.151.6.1551
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
