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The calcium‐binding proteins MRP8 and MRP14 form a membrane‐associated heterodimer in a subset of monocytes/macrophages present in acute but absent in chronic inflammatory lesions
Abstract
Monocytes/macrophages expressing an epitope recognized by a monoclonal antibody 27E10 are present in acute but are absent in chronic inflammatory disorders. This report shows that the 27E10 antigen is formed by noncovalent association of the two Ca 2+‐binding proteins MRP8 and MRP14 which belong to the S100 protein family. Identification has been confirmed immunochemically, by matrix‐assisted UV‐laser desorption/ionization spectrometry and by partial amino acid sequencing. Surface expression of the MRP8/MRP14 complex on a subset of monocytes is reported for the first time and shown to be up‐regulated in a Ca 2+‐dependent manner. The 27E10 surface‐positive monocytes isolated by cell separation techniques release high amounts of tumor necrosis factor‐α and interleukin‐1β in contrast to their 27E10 surface‐negative counterparts thus emphasizing their role in inflammation.
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Citations
Cited by
Adipokine dysregulation and adipose tissue inflammation in human obesity
Unamuno, X., Gómez‐Ambrosi, J., Rodríguez, A., Becerril, S., Frühbeck, G., & Catalán, V. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.12997 · Cited by 610
Calprotectin – a pleiotropic molecule in acute and chronic inflammation.
Stříž, I., & Trebichavský, I. (2004) · Physiological Research · doi:10.33549/physiolres.930448 · Cited by 466
Multiple sclerosis: In situ evidence for antibody‐ and complement‐mediated demyelination
Storch, M. K., Piddlesden, S., Haltia, M., Iivanainen, M., Morgan, P., & Lassmann, H. (1998) · Annals of Neurology · doi:10.1002/ana.410430409 · Cited by 422
Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9)
Kerkhoff, C., Klempt, M., & Sorg, C. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(98)00144-x · Cited by 276
Self-citationThe Human S100 Protein MRP-14 Is a Novel Activator of the β2 Integrin Mac-1 on Neutrophils
Newton, R. A., & Hogg, N. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.3.1427 · Cited by 253
Metadata
- Authors
- Bhardwaj, R. S., Zotz, C., Roth, J., Goebeler, M., Mahnke, K., Falk, M., Meinardus‐Hager, G., Sorg, C., & Zwadlo‐Klarwasser, G.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1992-07
- Volume
- 22
- Issue
- 7
- Pages
- 1891-1897
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2035913788
- Cited by
- 185
- References
- 0
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The calcium‐binding proteins MRP8 and MRP14 form a membrane‐associated heterodimer in a subset of monocytes/macrophages present in acute but absent in chronic inflammatory lesions. https://app.cochat.ai/papers/10.1002/eji.1830220732
- The paper
- Bhardwaj, R. S., Zotz, C., Roth, J., Goebeler, M., Mahnke, K., Falk, M., Meinardus‐Hager, G., Sorg, C., & Zwadlo‐Klarwasser, G. (1992). The calcium‐binding proteins MRP8 and MRP14 form a membrane‐associated heterodimer in a subset of monocytes/macrophages present in acute but absent in chronic inflammatory lesions. European Journal of Immunology. https://doi.org/10.1002/eji.1830220732
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