The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Calprotectin – a pleiotropic molecule in acute and chronic inflammation.
Open accessAbstract
Calprotectin (MRP8/14, S100A8/S100A9, 27E10 antigen) is a heterodimer of two calcium-binding proteins present in the cytoplasm of neutrophils and expressed on the membrane of monocytes. Upon neutrophil activation or endothelial adhesion of monocytes, calprotectin is released and may be detected in serum or body fluids as potentially useful clinical inflammatory marker. The soluble form of calprotectin provides both bacteriostatic and cytokine-like effects in the local environment. When calprotectin metabolism is affected on a systemic level, the zinc-binding properties of protein may induce severe dysregulation of zinc homeostasis with severe clinical symptoms. The distribution of membrane form of calprotectin is restricted to monocytes and immature macrophages and the presence of calprotectin-positive infiltrating cells reflects the influx of mononuclear phagocytes to the site of inflammation. Calprotectin expression and release seems to be of particular importance in immune and immunopathological reactions.
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Cites
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Rage and arthritis: The G82S polymorphism amplifies the inflammatory response
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Neutrophils and immunity: challenges and opportunities
Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971
Zinc as a Gatekeeper of Immune Function
Wessels, I., Maywald, M., & Rink, L. (2017) · Nutrients · doi:10.3390/nu9121286 · Cited by 747
NETs: a new strategy for using old weapons
Papayannopoulos, V., & Zychlinsky, A. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.07.011 · Cited by 634
Biomarkers in acute kidney injury – pathophysiological basis and clinical performance
Schrezenmeier, E. V., Barasch, J., Budde, K., Westhoff, T., & Schmidt‐Ott, K. M. (2017) · Acta Physiologica · doi:10.1111/apha.12764 · Cited by 401
A Role for Zinc in Plant Defense Against Pathogens and Herbivores
Cabot, C., Martos, S., Llugany, M., Gallego, B., Tolrà, R., & Poschenrieder, C. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.01171 · Cited by 363
Metadata
- Authors
- Stříž, I., & Trebichavský, I.
- Venue
- Physiological Research
- Published
- 2004
- Volume
- 53
- Issue
- 3
- Pages
- 245-253
- ISSN
- 0862-8408 (ISSN-L)
- 1802-9973
- OpenAlex
- W2182047966
- Cited by
- 466
- References
- 42
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
