The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction
Abstract
Previous studies on the production of interleukin‐12 (IL‐12) have shown that it is released, together with other proinflammatory cytokines, shortly after exposure of phagocytic cells to a variety of pathogens. We here report that IL‐12 is also released during the recall response to soluble antigen (Ag) devoid of intrinsic adjuvant activity. We show that activated T cells induce the production of IL‐12 by monocytes via a mechanism involving the interaction of T cell‐associated CD40 ligand with CD40 on monocytes. The data suggest that Ag presentation on monocytes favors the persistence of type 1 responses.
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Cites
Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages
Hsieh, C.-S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A., & Murphy, K. M. (1993) · Science · doi:10.1126/science.8097338 · Cited by 3,134
IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
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Interleukin-12 and its role in the generation of TH1 cells
Trinchieri, G. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90230-i · Cited by 845
Gazzinelli, R. T., Hieny, S., Wynn, T. A., Wolf, S., & Sher, A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6115 · Cited by 835
Induction of TH1 and TH2 responses: a key role for the ‘natural’ immune response?
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Cited by
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
Bennett, S. R. M., Carbone, F. R., Karamalis, F., Flavell, R. A., Miller, J. F. A. P., & Heath, W. R. (1998) · Nature · doi:10.1038/30996 · Cited by 2,092
CD40 AND CD154 IN CELL-MEDIATED IMMUNITY
Grewal, I. S., & Flavell, R. A. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.111 · Cited by 1,539
Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity
Trinchieri, G. (1998) · Advances in Immunology · doi:10.1016/s0065-2776(08)60387-9 · Cited by 760
Clinical spectrum of X-linked hyper-IgM syndrome
Levy, J., Espanol-Boren, T., Thomas, C., Fischer, A., Tovo, P., Bordigoni, P., Resnick, I., Fasth, A., Baer, M., Gomez, L., et al. (1997) · The Journal of Pediatrics · doi:10.1016/s0022-3476(97)70123-9 · Cited by 655
Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses
Gramaglia, I., Weinberg, A. D., Lemon, M., & Croft, M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.12.6510 · Cited by 527
Metadata
- Authors
- Shu, U., Kiniwa, M., Wu, C. Y., Maliszewski, C., Vezzio, N., Hakimi, J., Gately, M., & Delespesse, G.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1995-04
- Volume
- 25
- Issue
- 4
- Pages
- 1125-1128
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2075942913
- Cited by
- 414
- References
- 18
- FWCI
- 19.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction. https://app.cochat.ai/papers/10.1002/eji.1830250442
- The paper
- Shu, U., Kiniwa, M., Wu, C. Y., Maliszewski, C., Vezzio, N., Hakimi, J., Gately, M., & Delespesse, G. (1995). Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction. European Journal of Immunology. https://doi.org/10.1002/eji.1830250442
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
