The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40.
Open accessAbstract
CD40 is a member of the tumor necrosis factor (TNF) receptor family of cell surface proteins and was originally described as a B cell restricted antigen. Treatment of primary human monocytes with granulocyte/macrophage colony-stimulating factor (GM-CSF), interleukin 3 (IL-3), or interferon gamma (IFN-gamma) resulted in the induction of CD40 mRNA and enhancement of cell surface protein expression. CD40 was found to mediate monocyte adhesion to cells expressing recombinant CD40 ligand. CD40 ligand-transfected cells provided a potent costimulus for monocyte TNF-alpha and IL-6 production in the presence of GM-CSF, IL-3, or IFN-gamma, and enhanced IL-8 production stimulated by GM-CSF or IL-3. In addition, CD40 ligand-transfected cells acting in the absence of a costimulus induced monocytes to become tumoricidal against a human melanoma cell target. Collectively, these data indicate that CD40 ligand is pleiotropic with potent biological activity on monocytes.
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Citations
Cites
Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.
Le, J., & Vilček, J. (1987) · PubMed · Cited by 1,327
Molecular and biological characterization of a murine ligand for CD40
Armitage, R. J., Fanslow, W. C., Strockbine, L., Sato, T. A., Clifford, K. N., Macduff, B. M., Anderson, D. M., Gimpel, S. D., Davis-Smith, T., Maliszewski, C. R., et al. (1992) · Nature · doi:10.1038/357080a0 · Cited by 1,022
Self-citationA novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.
McMahan, C. J., Slack, J. L., Mosley, B., Cosman, D., Lupton, S. D., Brunton, L. L., Grubin, C. E., Wignall, J. M., Jenkins, N. A., & Brannan, C. I. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07831.x · Cited by 677
Hollenbaugh, D., Grosmaire, L. S., Kullas, C. D., Chalupny, N. J., Braesch-Andersen, S., Noelle, R. J., Stamenkovic, I., Ledbetter, J. A., & Aruffo, A. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05530.x · Cited by 511
Jabara, H. H., Fu, S. M., Geha, R. S., & Vercelli, D. (1990) · The Journal of experimental medicine · doi:10.1084/jem.172.6.1861 · Cited by 444
Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion.
Spriggs, M. K., Armitage, R. J., Strockbine, L. D., Clifford, K. N., Macduff, B. M., Sato, T., Maliszewski, C. R., & Fanslow, W. C. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.6.1543 · Cited by 388
Self-citationTumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.
Urban, J. L., Shepard, H. M., Rothstein, J. L., Sugarman, B. J., & Schreiber, H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.14.5233 · Cited by 358
Modulation of phenotypic and functional properties of human peripheral blood monocytes by IL-4.
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Cloning of TRAP, a ligand for CD40 on human T cells
Graf, D., Korthäuer, U., Mages, H. W., Senger, G., & Kroczek, R. A. (1992) · European Journal of Immunology · doi:10.1002/eji.1830221226 · Cited by 280
CD40 is functionally expressed on human thymic epithelial cells
Galy, A. H., & Spits, H. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.3.775 · Cited by 255
Cited by
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
Bennett, S. R. M., Carbone, F. R., Karamalis, F., Flavell, R. A., Miller, J. F. A. P., & Heath, W. R. (1998) · Nature · doi:10.1038/30996 · Cited by 2,092
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
Henn, V., Slupsky, J. R., Gräfe, M., Anagnostopoulos, I., Förster, R., Müller-Berghaus, G., & Kroczek, R. A. (1998) · Nature · doi:10.1038/35393 · Cited by 2,078
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
Larsen, C. P., Elwood, E. T., Alexander, D. Z., Ritchie, S. C., Hendrix, R., Tucker-Burden, C., Cho, H. R., Aruffo, A., Hollenbaugh, D., Linsley, P. S., et al. (1996) · Nature · doi:10.1038/381434a0 · Cited by 1,455
Activation of human dendritic cells through CD40 cross-linking.
Caux, C., Massacrier, C., Vanbervliet, B., Dubois, B., Van Kooten, C., Durand, I., & Banchereau, J. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.4.1263 · Cited by 1,317
Mach, F., Schönbeck, U., Sukhova, G. K., Bourcier, T., Bonnefoy, J.-Y., Pober, J. S., & Libby, P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.1931 · Cited by 732
Metadata
- Authors
- Alderson, M. R., Armitage, R. J., Tough, T. W., Strockbine, L., Fanslow, W. C., & Spriggs, M. K.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1993-08-01
- Volume
- 178
- Issue
- 2
- Pages
- 669-674
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2133128339
- Cited by
- 578
- References
- 22
- FWCI
- 13.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. https://app.cochat.ai/papers/10.1084/jem.178.2.669
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- Alderson, M. R., Armitage, R. J., Tough, T. W., Strockbine, L., Fanslow, W. C., & Spriggs, M. K. (1993). CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. The Journal of experimental medicine. https://doi.org/10.1084/jem.178.2.669
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
