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Cited by 3,134T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Response and Inflammation

Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages

Hsieh, Chyi-Song, Macatonia, Steven E., Tripp, Catherine S., Wolf, Stanley F., O'Garra, Anne, Murphy, Kenneth M.·1993·Science
DOI 10.1126/science.8097338
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Abstract

Development of the appropriate CD4 + T helper (T H ) subset during an immune response is important for disease resolution. With the use of naive, ovalbumin-specific αβ T cell receptor transgenic T cells, it was found that heat-killed Listeria monocytogenes induced T H 1 development in vitro through macrophage production of interleukin-12 (IL-12). Moreover, inhibition of macrophage production of IL-12 may explain the ability of IL-10 to suppress T H 1 development. Murine immune responses to L. monocytogenes in vivo are of the appropriate T H 1 phenotype. Therefore, this regulatory pathway may have evolved to enable innate immune cells, through interactions with microbial pathogens, to direct development of specific immunity toward the appropriate T H phenotype.

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Crossref · 10.1126/science.8097338

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41 of 41 references verified0 citation errors · 0 not checkable

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  • Priming of Th1 cells by IL-12 and IFN-γ results in expression of the master transcription factor T-bet.

    “Priming of Th1 cells by IL-12 [188] and IFN-γ [189] results in expression of their master transcription factor T-bet [190]”

    From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [188]

  • IL-12 is critical for developing Th1 cells.

    “IL-12 is critical for developing Th1 cells, and IL-12 produced by macrophages can modulate the Th1 immune response during re-infection with Listeria monocytogenes [24].”

    From The Emerging Fungal Pathogen Candida auris Induces IFNγ to Colonize the Skin (2025) · cites this paper as [24]

  • IL-12 produced by macrophages can modulate the Th1 immune response during re-infection with Listeria monocytogenes.

    “IL-12 is critical for developing Th1 cells, and IL-12 produced by macrophages can modulate the Th1 immune response during re-infection with Listeria monocytogenes [24].”

    From The Emerging Fungal Pathogen Candida auris Induces IFNγ to Colonize the Skin (2025) · cites this paper as [24]

  • IL-12 produced by macrophages modulates the Th1 immune response during re-infection with L. monocytogenes.

    “Previous findings suggest that IL-12 produced by macrophages modulates the Th1 immune response during re-infection with L. monocytogenes [24].”

    From The Emerging Fungal Pathogen Candida auris Induces IFNγ to Colonize the Skin (2025) · cites this paper as [24]

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Authors
Hsieh, C.-S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A., & Murphy, K. M.
Affiliations
  • Washington University in St. Louis (US)
  • DNAX Research Institute of Molecular and Cellular Biology Inc., Palo Alto, CA 94304.
  • Genetics Institute Inc., Cambridge, MA 02140.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1993-04-23
Volume
260
Issue
5107
Pages
547-549
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.8097338
OpenAlex
W1979514172
Cited by
3,134
References
41
Citations by year
2026: 16 · 2025: 38 · 2024: 36 · 2023: 37 · 2022: 58 · 2021: 52 · 2020: 62 · 2019: 63 · 2018: 52 · 2017: 71 · 2016: 66 · 2015: 79 · 2014: 84 · 2013: 64 · 2012: 65
FWCI
78.79
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service (1 PO1 A131238-01)
  • National Institute of General Medical Sciences (5 T32 GM07200-17, T32GM007200)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
Th1 cells, CD4+ T cells, IL-12, Listeria monocytogenes, macrophages, IL-10, T cell differentiation, ovalbumin-specific T cells, transgenic T cells, innate immunity, immune regulation
MeSH terms
Animals, Cell Differentiation, Cells, Cultured, Interferon-gamma, Interleukin-2, Interleukins, Listeria monocytogenes, Macrophages, Mice, Transgenic, Phenotype, CD4-Positive T-Lymphocytes, Receptors, Antigen, T-Cell, alpha-beta, Interleukin-10, Interleukin-12, Mice

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