The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
An IgG‐transporting Fc receptor expressed in the syncytiotrophoblast of human placenta
Abstract
During normal human pregnancy, maternal IgG crosses the placenta and provides passive immunity for the fetus. In so doing, IgG passes through two cellular barriers: the syncytiotrophoblast and the fetal capillary endothelium. The Fc region of IgG is required for its transport across the placenta, but the Fc receptors responsible have not been identified definitively. We recently reported the isolation from a placental cDNA library of clones encoding the alpha chain of a human homologue of the major histocompatibility complex class I-related Fc receptor, the neonatal Fc receptor (FcRn). In mice, FcRn is essential for the transport of maternal IgG to the fetus and the neonate. We report here the localization of human FcRn mRNA within the placenta by in situ hybridization, and of human FcRn protein by immunohistochemistry. Both methods show that human FcRn is expressed in syncytiotrophoblast, and is, thus, appropriately located to transport maternal IgG across the first barrier. We confirm previous findings that specific binding of IgG to placental membranes is greater at pH 6.0 than pH 7.5. This corresponds with the pH dependence of IgG binding to FcRn and is consistent with the presence of FcRn in syncytiotrophoblast. We propose a transport model in which maternal IgG binds FcRn at low pH in endosomes within the syncytiotrophoblast. FcRn is not expressed in fetal capillary endothelia, and the mechanism of IgG transport across the second barrier remains unknown.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Various studies using immunohistochemical staining of placental sections with anti-FcRn antibodies have shown a mix of some (61, 62) or no (36).”
From Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy (2017) · cites this paper as [36]
Citations
Cites
β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells
Zijlstra, M., Bix, M., Simister, N. E., Loring, J. M., Raulet, D. H., & Jaenisch, R. (1990) · Nature · doi:10.1038/344742a0 · Cited by 1,009
Self-citationAn Fc receptor structurally related to MHC class I antigens
Simister, N. E., & Mostov, K. E. (1989) · Nature · doi:10.1038/337184a0 · Cited by 729
Self-citationHuman IgG Fc receptor heterogeneity: molecular aspects and clinical implications
van de Winkel, J. G. J., & Capel, P. J. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90166-i · Cited by 703
The transmission of passive immunity from mother to young
Brambell, F. W. R. (1970) · Cited by 616
Gitlin, D., & Biasucci, A. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106109 · Cited by 369
Story, C. M., Mikulska, J., & Simister, N. E. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.6.2377 · Cited by 354
Self-citationCrystal structure at 2.2 Å resolution of the MHC-related neonatal Fc receptor
Burmeister, W. P., Gastinel, L. N., Simister, N. E., Blum, M. L., & Björkman, P. J. (1994) · Nature · doi:10.1038/372336a0 · Cited by 336
Self-citationThe mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat
Jones, E. A., & Waldmann, T. A. (1972) · Journal of Clinical Investigation · doi:10.1172/jci107116 · Cited by 287
Distribution of β2 microglobulin and HLA in chorionic villi of human placentae
Faulk, W. P., & Temple, A. (1976) · Nature · doi:10.1038/262799a0 · Cited by 248
Israel, E. J., Patel, V., Taylor, S. F., Marshak‐Rothstein, A., & Simister, N. E. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.12.6246 · Cited by 192
Self-citation
Research works printed but not linked: 6
- Bright N. A., 1994, J. Anat., 184, 297
- Mackenzie N. M., 1984, Immunology, 51, 529
- Balfour A. H., 1977, Clin. Sci. Mol. Med., 52, 383
- Brown P. J., 1981, Immunology, 42, 313
- Sedmak D. D., 1991, Am. J. Pathol., 138, 175
- Wainwright S. D., 1993, Immunology, 80, 343
Cited by
Sorted by citations
FcRn: the neonatal Fc receptor comes of age
Roopenian, D. C., & Akilesh, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2155 · Cited by 2,346
IgG placental transfer in healthy and pathological pregnancies
Palmeira, P., Quinello, C., Silveira-Lessa, A. L., Zago, C. A., & Carneiro-Sampaio, M. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/985646 · Cited by 1,037
Placental transport of immunoglobulin G
Simister, N. (2003) · Vaccine · doi:10.1016/s0264-410x(03)00334-7 · Cited by 783
Self-citationTranscytosis: Crossing Cellular Barriers
TUMA, P. L., & HUBBARD, A. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00001.2003 · Cited by 681
Diagnosis and Management of Human Cytomegalovirus Infection in the Mother, Fetus, and Newborn Infant
Revello, M. G., & Gerna, G. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.4.680-715.2002 · Cited by 614
Metadata
- Authors
- Simister, N. E., Story, C. M., Chen, H., & Hunt, J. S.
- Affiliations
- Brandeis University (US)
- University of Kansas Medical Center (US)
- Corresponding author
- Simister, Neil E.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1996-07
- Volume
- 26
- Issue
- 7
- Pages
- 1527-1531
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W1986652140
- Cited by
- 332
- References
- 43
- Citations by year
- 2026: 14 · 2025: 14 · 2024: 14 · 2023: 7 · 2022: 18 · 2021: 16 · 2020: 14 · 2019: 15 · 2018: 17 · 2017: 13 · 2016: 13 · 2015: 10 · 2014: 13 · 2013: 10 · 2012: 14
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hd026429-08)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 26429, R01HD027691, HD27691)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- neonatal Fc receptor, syncytiotrophoblast, placenta, IgG transport, endosomal recycling
- MeSH terms
- Amino Acid Sequence, Binding Sites, Antibody, Biological Transport, Female, Humans, Hydrogen-Ion Concentration, Immunoglobulin Fc Fragments, Membranes, Molecular Sequence Data, Pregnancy, RNA, Messenger, Trophoblasts, Receptors, IgG
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
