The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Frontline: Neuropilin‐1: a surface marker of regulatory T cells
Open accessAbstract
CD4 + CD25 + regulatory T cells (T reg cells) control immune responsiveness to a large variety of antigens. The isolation and therapeutic manipulation of T reg cells requires the use of reliable surface receptors that are selectively up‐regulated in T reg cells. On the basis of global gene expression studies, we identified neuropilin‐1 (Nrp1) as a specific surface marker for CD4 + CD25 + T reg cells. Nrp1, a receptor involved in axon guidance, angiogenesis, and the activation of T cells, is constitutively expressed on the surface of CD4 + CD25 + T reg cells independently of their activation status. In contrast, Nrp1 expression is down‐regulated in naive CD4 + CD25 – T cells after TCR stimulation. Furthermore, CD4 + Nrp1 high T cells express high levels of Foxp3 and suppress CD4 + CD25 – T cells. Thus, Nrp1 constitutes a useful surface marker to distinguish T reg cells from both naive and recently activated CD4 + CD25 + non‐regulatory T cells.
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Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
CD4+CD25+ Immunoregulatory T Cells
McHugh, R. S., Whitters, M. J., Piccirillo, C. A., Young, D. A., Shevach, E. M., Collins, M., & Byrne, M. C. (2002) · Immunity · doi:10.1016/s1074-7613(02)00280-7 · Cited by 1,395
Cited by
Role of LAG-3 in Regulatory T Cells
Huang, C.-T., Workman, C. J., Flies, D., Pan, X., Marson, A. L., Zhou, G., Hipkiss, E. L., Ravi, S., Kowalski, J., Levitsky, H. I., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.010 · Cited by 1,325
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
Marson, A., Kretschmer, K., Frampton, G. M., Jacobsen, E. S., Polansky, J. K., MacIsaac, K. D., Levine, S. S., Fraenkel, E., von Boehmer, H., & Young, R. A. (2007) · Nature · doi:10.1038/nature05478 · Cited by 724
Mechanisms of Immune Evasion by Tumors
Drake, C. G., Jaffee, E., & Pardoll, D. M. (2006) · Advances in Immunology · doi:10.1016/s0065-2776(06)90002-9 · Cited by 688
Casazza, A., Laoui, D., Wenes, M., Rizzolio, S., Bassani, N., Mambretti, M., Deschoemaeker, S., Van Ginderachter, J. A., Tamagnone, L., & Mazzone, M. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.11.007 · Cited by 629
Weiss, J. M., Bilate, A. M., Gobert, M., Ding, Y., Curotto de Lafaille, M. A., Parkhurst, C. N., Xiong, H., Dolpady, J., Frey, A. B., Ruocco, M. G., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120914 · Cited by 621
Metadata
- Authors
- Bruder, D., Probst‐Kepper, M., Westendorf, A. M., Geffers, R., Beissert, S., Loser, K., von Boehmer, H., Buer, J., & Hansen, W.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2004-02-25
- Volume
- 34
- Issue
- 3
- Pages
- 623-630
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2059377172
- Cited by
- 453
- References
- 3
- FWCI
- 16.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bruder, D., Probst‐Kepper, M., Westendorf, A. M., Geffers, R., Beissert, S., Loser, K., von Boehmer, H., Buer, J., & Hansen, W. (2004). Frontline: Neuropilin‐1: a surface marker of regulatory T cells. European Journal of Immunology. https://doi.org/10.1002/eji.200324799
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