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Cited by 77Inflammatory Bowel DiseaseChemokine receptors and signalingOcular Diseases and Behçet’s Syndrome

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

CXCR1‐binding chemokines in inflammatory bowel diseases: down‐regulated IL‐8/CXCL8 production by leukocytes in Crohn's disease and selective GCP‐2/CXCL6 expression in inflamed intestinal tissue

Gijsbers, Klara, Van Assche, Gert, Joossens, Sofie, Struyf, Sofie, Proost, Paul, Rutgeerts, Paul, Geboes, Karel, Van Damme, Jo·2004·European Journal of Immunology
DOI 10.1002/eji.200324807
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Abstract

Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) that are characterized by chronic intestinal inflammation and a constant influx of leukocytes mediated by pro‐inflammatory cytokines and chemokines. The intestinal expression of the CXCR1‐binding chemokines IL‐8/CXCL8 and GCP‐2/CXCL6 and the participation of immunocompetent cells in IBD were evaluated. IL‐8 production by peripheral blood mononuclear cells (PBMC) from IBD patients, stimulated with endotoxin, plant lectin or double‐stranded RNA, was significantly lowered in patients with CD, but not in UC patients or healthy subjects. The reduced chemokine production by PBMC from IBD patients was both IL‐8 and CD specific, but not inducer dependent. In serum, most chemokines remained undetectable, while the levels of those that were measurable remained unaltered in IBD patients. GCP‐2, but not ENA‐78/CXCL5, nor IL‐8, were highly expressed by endothelial cells in inflamed intestinaltissue of IBD patients. In contrast, stimulated endothelial cell cultures produced more IL‐8 than GCP‐2. The selective GCP‐2 staining of endothelial cells at sites of ulcerations suggests that GCP‐2, despite its low production capacity in vitro, plays a role in IBD that is different from that of structurally (ENA‐78) and functionally (IL‐8) related ELR+ CXC chemokines. Thus, the chemokine network shows complementarity rather than redundancy.

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Crossref · 10.1002/eji.200324807

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  • IL-8 is important in inflammatory diseases such as psoriasis, Crohn's disease, and cancer.

    “The importance of IL-8 has made this chemokine important in inflammatory diseases such as psoriasis, Crohn’s disease, and cancer (80, 81).”

    From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [81]

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  1. 10.1182/blood.V90.3.909 · DOI

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Metadata

Authors
Gijsbers, K., Van Assche, G., Joossens, S., Struyf, S., Proost, P., Rutgeerts, P., Geboes, K., & Van Damme, J.
Affiliations
  • Rega Institute for Medical Research (BE)
  • Universitair Ziekenhuis Leuven (BE)
ORCID
Venue
European Journal of Immunology
Publisher
Wiley
Published
2004-06-15
Volume
34
Issue
7
Pages
1992-2000
ISSN
  • 0014-2980 (ISSN-L)
  • 1521-4141
DOI
10.1002/eji.200324807
OpenAlex
W2026546599
Cited by
77
References
44
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 1 · 2015: 5 · 2014: 4 · 2012: 1
FWCI
2.14
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • European Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Vlaamse regering
Topics
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords
Crohn's disease, ulcerative colitis, inflammatory bowel disease, IL-8/CXCL8, peripheral blood mononuclear cells, endothelial cells, intestinal inflammation, leukocyte recruitment, ELR+ CXC chemokines
MeSH terms
Crohn Disease, Enzyme-Linked Immunosorbent Assay, Humans, Immunohistochemistry, Inflammation, Intestinal Mucosa, Intestines, Leukocytes, Down-Regulation, Interleukin-8, Chemokines, CXC, Receptors, Interleukin-8A, Intercellular Signaling Peptides and Proteins, Endothelial Cells, Chemokine CXCL6

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