The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Syk‐dependent ERK activation regulates IL‐2 and IL‐10 production by DC stimulated with zymosan
Abstract
Zymosan is a particulate yeast preparation that elicits high levels of IL‐2 and IL‐10 from dendritic cells (DC) and engages multiple innate receptors, including the Syk‐coupled receptor dectin‐1 and the MyD88‐coupled receptor TLR2. Here, we show that induction of IL‐2 and IL‐10 by zymosan requires activation of ERK MAP kinase in murine DC. Surprisingly, ERK activation in response to zymosan is completely blocked in Syk‐deficient DC and unaffected by MyD88 deficiency. Conversely, ERK activation in response to the TLR2 agonist Pam3Cys is completely MyD88 dependent and unaffected by Syk deficiency. The inability of TLR2 ligands in zymosan to couple to ERK may explain the Syk dependence of the IL‐2 and IL‐10 response in DC and emphasises the importance of Syk‐coupled pattern recognition receptors such as dectin‐1 in the detection of yeasts. Furthermore, the lack of receptor compensation observed here suggests that responses induced by complex innate stimuli cannot always be predicted by the signalling pathways downstream of individual receptors.
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Citations
Cites
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
Brown, G. D., & Gordon, S. (2001) · Nature · doi:10.1038/35092620 · Cited by 1,579
Self-citationLucas, M., Zhang, X., Prasanna, V., & Mosser, D. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.469 · Cited by 197
Cited by
The SYK tyrosine kinase: A crucial player in diverse biological functions
Mócsai, A., Ruland, J., & Tybulewicz, V. L. J. (2010) · Nature Reviews Immunology · doi:10.1038/nri2765 · Cited by 1,368
Self-citationAn integrated model of the recognition of Candida albicans by the innate immune system
Netea, M. G., Brown, G. D., Kullberg, B. J., & Gow, N. A. R. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1815 · Cited by 946
Self-citationβ‐glucan recognition by the innate immune system
Goodridge, H. S., Wolf, A. J., & Underhill, D. M. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00793.x · Cited by 688
Robinson, M. J., Osorio, F., Rosas, M., Freitas, R. P., Schweighoffer, E., Groß, O., Verbeek, J. S., Ruland, J., Tybulewicz, V., Brown, G. D., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082818 · Cited by 462
Self-citationPattern recognition: recent insights from Dectin-1
Reid, D. M., Gow, N. A., & Brown, G. D. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.01.003 · Cited by 289
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Metadata
- Authors
- Slack, E. C., Robinson, M. J., Hernanz‐Falcón, P., Brown, G. D., Williams, D. L., Schweighoffer, E., Tybulewicz, V. L., & Reis e Sousa, C.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2007-05-24
- Volume
- 37
- Issue
- 6
- Pages
- 1600-1612
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2068977602
- Cited by
- 161
- References
- 3
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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