Th17 and regulatory T cells in mediating and restraining inflammation
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The vertebrate immune system is poised in a state of equilibrium that permits accurate and rapid protective responses against pathogens but curtails potential for causing harm to the host through targeting of "self" and provoking overexuberant inflammatory processes. In this Review we discuss this balance achieved in large part by interactions of different classes of T lymphocytes that have potent pro- or anti-inflammatory activity in the context of genetic and environmental factors, particularly the commensal microbiota.
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Th17 cells have well-established pathological actions in other diseases.
“The well-established pathological actions of Th17 cells in other diseases (45–47)”
From Inflammatory T helper 17 cells promote depression-like behavior in mice (2013) · cites this paper as [46]
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- Authors
- Littman, D. R., & Rudensky, A. Y.
- Affiliations
- Howard Hughes Medical Institute (US)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Littman, Dan R.
- Rudensky, Alexander Y.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 140
- Issue
- 6
- Pages
- 845-858
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2103600875
- Cited by
- 1,039
- References
- 20
- Citations by year
- 2026: 17 · 2025: 43 · 2024: 70 · 2023: 60 · 2022: 46 · 2021: 58 · 2020: 44 · 2019: 54 · 2018: 45 · 2017: 77 · 2016: 65 · 2015: 77 · 2014: 78 · 2013: 78 · 2012: 92
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- Th17 cells, regulatory T cells, inflammation, immune homeostasis, commensal microbiota, self-tolerance
- MeSH terms
- Bacteria, T-Lymphocytes, Helper-Inducer, Immune Tolerance, Inflammation, Intestinal Mucosa, T-Lymphocytes, Regulatory
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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