The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Interleukin-17 promotes angiogenesis and tumor growth
Abstract
Interleukin-17 (IL-17) is a CD4 T-cell-derived proinflammatory cytokine. We investigated the effects of locally produced IL-17 by tumors as a means to evaluate its biologic function. Although recombinant IL-17 protein or retroviral transduction of IL-17 gene into tumors did not affect in vitro proliferation, IL-17 transfectants grew more rapidly in vivo when compared with controls. Immunostaining for Factor VIII revealed that tumors transduced with IL-17 had significantly higher vascular density when compared with controls. IL-17 indeed elicited neovascularization in rat cornea. In addition, angiogenic activity present in the conditioned media of CD4 T cells was markedly suppressed by neutralizing monoclonal antibody to IL-17. IL-17 had no direct effect on the growth of vascular endothelial cells, whereas IL-17 significantly stimulated migration. IL-17 also markedly promoted the cord formation of vascular endothelial cells. In addition, IL-17 up-regulated elaboration of a variety of proangiogenic factors by fibroblasts as well as tumor cells. These findings reveal a novel role for IL-17 as a CD4 T-cell-derived mediator of angiogenesis that stimulates vascular endothelial cell migration and cord formation and regulates production of a variety of proangiogenic factors. Furthermore, they suggest that inhibition of biologic action of IL-17 may have therapeutic benefits when applied to angiogenesis-related disorders.
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Metadata
- Authors
- Numasaki, M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2002-10-31
- Volume
- 101
- Issue
- 7
- Pages
- 2620-2627
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2000102677
- Cited by
- 834
- References
- 40
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- closed
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