The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
IL‐6: Regulator of Treg/Th17 balance
Abstract
IL‐6 is a pleiotropic cytokine involved in the physiology of virtually every organ system. Recent studies have demonstrated that IL‐6 has a very important role in regulating the balance between IL‐17‐producing Th17 cells and regulatory T cells (Treg). The two T‐cell subsets play prominent roles in immune functions: Th17 cell is a key player in the pathogenesis of autoimmune diseases and protection against bacterial infections, while Treg functions to restrain excessive effector T‐cell responses. IL‐6 induces the development of Th17 cells from naïve T cells together with TGF‐β; in contrast, IL‐6 inhibits TGF‐β‐induced Treg differentiation. Dysregulation or overproduction of IL‐6 leads to autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA), in which Th17 cells are considered to be the primary cause of pathology. Given the critical role of IL‐6 in altering the balance between Treg and Th17 cells, controlling IL‐6 activities is potentially an effective approach in the treatment of various autoimmune and inflammatory diseases. Here, we review the role of IL‐6 in regulating Th17/Treg balance and describe the critical functions of IL‐6 and Th17 in immunity and immune‐pathology.
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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
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Self-citationReciprocal T H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid
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Cited by
IL‐6 in inflammation, immunity, and disease
Tanaka, T., Narazaki, M., & Kishimoto, T. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016295 · Cited by 5,046
Self-citationCoperchini, F., Chiovato, L., Croce, L., Magri, F., & Rotondi, M. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.05.003 · Cited by 1,288
Multiple Sclerosis: Mechanisms and Immunotherapy
Baecher-Allan, C., Kaskow, B. J., & Weiner, H. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.021 · Cited by 938
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MicroRNA-155 Modulates Treg and Th17 Cells Differentiation and Th17 Cell Function by Targeting SOCS1
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Metadata
- Authors
- Kimura, A., & Kishimoto, T.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2010-06-25
- Volume
- 40
- Issue
- 7
- Pages
- 1830-1835
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2028195000
- Cited by
- 1,595
- References
- 18
- FWCI
- 20.72
- Type
- journal article
- Language
- en
- Open access
- closed
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