The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Enhanced protection to Mycobacterium tuberculosis infection in IL‐10‐deficient mice is accompanied by early and enhanced Th1 responses in the lung
Open accessAbstract
IL‐10 regulates the balance of an immune response between pathogen clearance and immunopathology. We show here that Mycobacterium tuberculosis ( Mtb ) infection in the absence of IL‐10 (IL‐10 −/− mice) results in reduced bacterial loads in the lung. This reduction was preceded by an accelerated and enhanced IFN‐γ response in the lung, an increased influx of CD4 + T cells into the lung, and enhanced production of chemokines and cytokines, including CXCL10 and IL‐17, in both the lung and the serum. Neutralization of IL‐17 affected neither the enhanced production of CXCL10 nor the accumulation of IFN‐γ‐producing T cells in the lungs, but led to reduced numbers of granulocytes in the lung and reduced bacterial loads in the spleens of Mtb ‐infected mice. This suggests that IL‐17 may contribute to dissemination of Mtb .
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Cites
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
Self-citationIdentification of nitric oxide synthase as a protective locus against tuberculosis
MacMicking, J. D., North, R. J., LaCourse, R., Mudgett, J. S., Shah, S. K., & Nathan, C. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5243 · Cited by 1,180
Wolf, A. J., Desvignes, L., Linas, B., Banaiee, N., Tamura, T., Takatsu, K., & Ernst, J. D. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071367 · Cited by 580
Belkaid, Y., Hoffmann, K. F., Mendez, S., Kamhawi, S., Udey, M. C., Wynn, T. A., & Sacks, D. L. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.10.1497 · Cited by 557
Cited by
Biology and therapeutic potential of interleukin-10
Saraiva, M., Vieira, P., & O’Garra, A. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20190418 · Cited by 1,118
Self-citationIL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation
Ouyang, W., & O’Garra, A. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.020 · Cited by 1,072
Self-citationThe role of IL-10 in immune regulation during M. tuberculosis infection
Redford, P. S., Murray, P. J., & O'Garra, A. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.7 · Cited by 472
Self-citationMayer-Barber, K. D., Andrade, B. B., Barber, D. L., Hieny, S., Feng, C. G., Caspar, P., Oland, S., Gordon, S., & Sher, A. (2011) · Immunity · doi:10.1016/j.immuni.2011.12.002 · Cited by 418
Intracellular Pathogens: Host Immunity and Microbial Persistence Strategies
Thakur, A., Mikkelsen, H., & Jungersen, G. (2019) · Journal of Immunology Research · doi:10.1155/2019/1356540 · Cited by 396
Metadata
- Authors
- Redford, P. S., Boonstra, A., Read, S., Pitt, J., Graham, C., Stavropoulos, E., Bancroft, G. J., & O'Garra, A.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2010-07-29
- Volume
- 40
- Issue
- 8
- Pages
- 2200-2210
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2074895894
- Cited by
- 233
- References
- 4
- FWCI
- 13.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Redford, P. S., Boonstra, A., Read, S., Pitt, J., Graham, C., Stavropoulos, E., Bancroft, G. J., & O'Garra, A. (2010). Enhanced protection to Mycobacterium tuberculosis infection in IL‐10‐deficient mice is accompanied by early and enhanced Th1 responses in the lung. European Journal of Immunology. https://doi.org/10.1002/eji.201040433
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
