The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Biology and therapeutic potential of interleukin-10
Open accessAbstract
The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from over-exuberant responses to pathogens and microbiota, while playing important roles in other settings as sterile wound healing, autoimmunity, cancer, and homeostasis. Here we discuss our current understanding of the regulation of IL-10 production and of the molecular pathways associated with IL-10 responses. In addition to IL-10’s classic inhibitory effects on myeloid cells, we also describe the nonclassic roles attributed to this pleiotropic cytokine, including how IL-10 regulates basic processes of neural and adipose cells and how it promotes CD8 T cell activation, as well as epithelial repair. We further discuss its therapeutic potential in the context of different diseases and the outstanding questions that may help develop an effective application of IL-10 in diverse clinical settings.
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Cites
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BackgroundSOCS3 negatively regulates IL-6 signaling in vivo
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Cited by
Shemer, A., Scheyltjens, I., Frumer, G. R., Kim, J.-S., Grozovski, J., Ayanaw, S., Dassa, B., Van Hove, H., Chappell-Maor, L., Boura-Halfon, S., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.09.018 · Cited by 175
Predictive Biomarkers for Checkpoint Inhibitor Immune-Related Adverse Events
Les, I., Martínez, M., Pérez-Francisco, I., Cabero, M., Teijeira, L., Arrazubi, V., Torrego, N., Campillo-Calatayud, A., Elejalde, I., Kochan, G., et al. (2023) · Cancers · doi:10.3390/cancers15051629 · Cited by 100
ASGR1 and its enigmatic relative, CLEC10A
Hoober, J. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144818 · Cited by 74
Metadata
- Authors
- Saraiva, M., Vieira, P., & O’Garra, A.
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2019-10-14
- Volume
- 217
- Issue
- 1
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2981100201
- Cited by
- 1,118
- References
- 23
- FWCI
- 21.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
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