The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Low-Cost Printing of Poly(dimethylsiloxane) Barriers To Define Microchannels in Paper
Open accessAbstract
This paper describes the use of a modified x,y-plotter to generate hydrophilic channels by printing a solution of hydrophobic polymer (pol(dimethylsiloxane; PDMS) dissolved in hexanes onto filter paper. The PDMS penetrates the depth of the paper and forms a hydrophobic wall that aqueous solutions cannot cross. The minimum size of printed features is approximately 1 mm; this resolution is adequate for the rapid prototyping of hand-held, visually read, diagnostic assays (and other microfluidic systems) based on paper. After curing the printed PDMS, the paper-based devices can be bent or folded to generate three-dimensional systems of channels. Capillary action pulls aqueous samples into the paper channels. Colorimetric assays for the presence of glucose and protein are demonstrated in the printed devices; spots of Bromothymol Blue distinguished samples with slightly basic pH (8.0) from samples with slightly acidic pH (6.5). The work also describes using printed devices that can be loaded using multipipets and printed flexible, foldable channels in paper over areas larger than 100 cm2.
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Cites
Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane)
Duffy, D. C., McDonald, J. C., Schueller, O. J. A., & Whitesides, G. M. (1998) · Analytical Chemistry · doi:10.1021/ac980656z · Cited by 5,288
Self-citationPatterned Paper as a Platform for Inexpensive, Low‐Volume, Portable Bioassays
Martinez, A. W., Phillips, S. T., Butte, M. J., & Whitesides, G. M. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200603817 · Cited by 2,874
Self-citationSolvent Compatibility of Poly(dimethylsiloxane)-Based Microfluidic Devices
Lee, J. N., Park, C., & Whitesides, G. M. (2003) · Analytical Chemistry · doi:10.1021/ac0346712 · Cited by 2,643
Self-citationMicrofluidic diagnostic technologies for global public health
Yager, P., Edwards, T., Fu, E., Helton, K., Nelson, K., Tam, M. R., & Weigl, B. H. (2006) · Nature · doi:10.1038/nature05064 · Cited by 1,979
Microfluidic devices fabricated in Poly(dimethylsiloxane) for biological studies
Sia, S. K., & Whitesides, G. M. (2003) · ELECTROPHORESIS · doi:10.1002/elps.200305584 · Cited by 1,717
Self-citationMicrofluidic platforms for lab-on-a-chip applications
Haeberle, S., & Zengerle, R. (2007) · Lab on a Chip · doi:10.1039/b706364b · Cited by 1,124
Diagnostics for the developing world
Mabey, D., Peeling, R. W., Ustianowski, A., & Perkins, M. D. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro841 · Cited by 1,054
Lab-on-a-chip devices for global health: Past studies and future opportunities
Chin, C. D., Linder, V., & Sia, S. K. (2007) · Lab Chip · doi:10.1039/b611455e · Cited by 811
Chaudhury, M. K., & Whitesides, G. M. (1991) · Langmuir · doi:10.1021/la00053a033 · Cited by 658
Self-citationEnsuring quality and access for malaria diagnosis: how can it be achieved?
Bell, D., Wongsrichanalai, C., & Barnwell, J. W. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1474 · Cited by 354
Cited by
Flexographically Printed Fluidic Structures in Paper
Olkkonen, J., Lehtinen, K., & Erho, T. (2010) · Analytical Chemistry · doi:10.1021/ac1027066 · Cited by 369
Metadata
- Authors
- Bruzewicz, D. A., Reches, M., & Whitesides, G. M.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-03-12
- Volume
- 80
- Issue
- 9
- Pages
- 3387-3392
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2172079391
- Cited by
- 616
- References
- 17
- FWCI
- 15.99
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
