Epigenetic regulation: The interface between prenatal and early‐life exposure and asthma susceptibility
Open accessAbstract
Asthma is a complex disease with genetic and environmental influences and emerging evidence suggests that epigenetic regulation is also a major contributor. Here, we focus on the developing paradigm that epigenetic dysregulation in asthma and allergy may start as early as in utero following several environmental exposures. We summarize the pathways important to the allergic immune response that are epigenetically regulated, the key environmental exposures associated with epigenetic changes in asthma genes, and newly identified epigenetic biomarkers that have been linked to clinical asthma. We conclude with a brief discussion about the potential to apply newly developing technologies in epigenetics to the diagnosis and treatment of asthma and allergy. The inherent plasticity of epigenetic regulation following environmental exposures offers opportunities for prevention using environmental remediation, measuring novel biomarkers for early identification of those at risk, and applying advances in pharmaco‐epigenetics to tailor medical therapies that maximize efficacy of treatment. ‘Precision Medicine’ in asthma and allergy is arriving. As the field advances this may involve an individually tailored approach to the prevention, early detection, and treatment of disease based on the knowledge of an individual's epigenetic profile. Environ. Mol. Mutagen. 55:231–243, 2014. © 2013 Wiley Periodicals, Inc.
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The link between prenatal PM2.5 exposure and the development of asthma has become increasingly recognized as epidemiologic studies have reported positive associations.
“The link between prenatal PM2.5 exposure and the development of asthma has also become increasingly recognized as epidemiologic studies have reported positive associations [6, 20].”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [20]
The Particulate Matter (PM) section reports positive associations between PM2.5 exposure and childhood asthma exacerbations or new wheeze, but it does not identify the exposure as prenatal or report an association with asthma development itself. The adjacent PAH section links exposure measured during pregnancy to increased childhood asthma risk, but PAH is not PM2.5. Page numbers are unavailable in our copy. (LLM, conf=0.87)
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Self-citation
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Cited by
Sorted by citations
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“have reported positive associations [6, 20].”
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- Authors
- de Planell‐Saguer, M., Lovinsky‐Desir, S., & Miller, R. L.
- Affiliations
- Division of Pulmonary Allergy and Critical Care Medicine Department of Medicine Columbia University College of Physicians and Surgeons New York New York
- Columbia University Irving Medical Center (US)
- Corresponding author
- Miller, Rachel L.
- Venue
- Environmental and Molecular Mutagenesis
- Publisher
- Wiley
- Published
- 2013-12-09
- Volume
- 55
- Issue
- 3
- Pages
- 231-243
- ISSN
- 0893-6692 (ISSN-L)
- 1098-2280
- PMC
- PMC4148423
- OpenAlex
- W2155611513
- Cited by
- 32
- References
- 123
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 1
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Environmental and Molecular Mutagenesis (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5T32HL105323, 2R01ES13163-6A1, P50 ES015905, RO1 ES020926 and R21 AI101296)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- asthma, epigenetic regulation, prenatal exposure, early life exposure, asthma susceptibility, allergy, allergic immune response, epigenetic biomarkers, precision medicine, asthma prevention, environmental remediation, epigenetic plasticity
- MeSH terms
- Adolescent, Asthma, Child, Child, Preschool, Dendritic Cells, Environmental Exposure, Female, T-Lymphocytes, Helper-Inducer, Humans, Hypersensitivity, Male, Pregnancy, Prenatal Exposure Delayed Effects, Biomarkers, Antigen Presentation, Gene Expression Regulation, Developmental, Maternal Exposure, Genetic Predisposition to Disease, Epigenesis, Genetic, T-Lymphocytes, Regulatory, Particulate Matter, Volatile Organic Compounds
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