The DOI matches its Crossref record; 174 of the 174 references it cites were found in a registry or an index.
DNA damage foci: Meaning and significance
Open accessAbstract
The discovery of DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double‐strand break to form microscopically visible, subnuclear foci, has revolutionized the detection of these lesions and has enabled studies of the cellular machinery that contributes to their repair. Double‐strand breaks are induced directly by a number of physical and chemical agents, including ionizing radiation and radiomimetic drugs, but can also arise as secondary lesions during replication and DNA repair following exposure to a wide range of genotoxins. Here we aim to review the biological meaning and significance of DNA damage foci, looking specifically at a range of different settings in which such markers of DNA damage and repair are being studied and interpreted. Environ. Mol. Mutagen. 56:491–504, 2015. © Wiley Periodicals, Inc.
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Cites
The DNA Damage Response: Making It Safe to Play with Knives
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Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo
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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
Gorgoulis, V. G., Vassiliou, L.-V. F., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., DiTullio, R. A., Kastrinakis, N. G., Levy, B., et al. (2005) · Nature · doi:10.1038/nature03485 · Cited by 2,009
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
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Self-citationPlaying the End Game: DNA Double-Strand Break Repair Pathway Choice
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Double-Strand Break End Resection and Repair Pathway Choice
Symington, L. S., & Gautier, J. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132435 · Cited by 1,493
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Self-citationDouble-strand break repair: 53BP1 comes into focus
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The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer
Alves-Fernandes, D. K., & Jasiulionis, M. G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133153 · Cited by 385
Do DNA Double-Strand Breaks Drive Aging?
White, R. R., & Vijg, J. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.08.004 · Cited by 232
Wang, X., Zhang, H., Bai, M., Ning, T., Ge, S., Deng, T., Liu, R., Zhang, L., Ying, G., & Ba, Y. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.01.001 · Cited by 192
Metadata
- Authors
- Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak‐Rothkamm, S.
- Venue
- Environmental and Molecular Mutagenesis
- Publisher
- Wiley
- Published
- 2015-03-12
- Volume
- 56
- Issue
- 6
- Pages
- 491-504
- ISSN
- 0893-6692 (ISSN-L)
- 1098-2280
- OpenAlex
- W1602963387
- Cited by
- 335
- References
- 174
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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