The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion
Open accessAbstract
The concept of 'field cancerization' describes the clonal expansion of genetically altered, but morphologically normal cells that predisposes a tissue to cancer development. Here, we demonstrate that biased stem cell competition in the mouse small intestine can initiate the expansion of such clones. We quantitatively analyze how the activation of oncogenic K-ras in individual Lgr5(+) stem cells accelerates their cell division rate and creates a biased drift towards crypt clonality. K-ras mutant crypts then clonally expand within the epithelium through enhanced crypt fission, which distributes the existing Paneth cell niche over the two new crypts. Thus, an unequal competition between wild-type and mutant intestinal stem cells initiates a biased drift that leads to the clonal expansion of crypts carrying oncogenic mutations.
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Cites
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., & Clevers, H. (2011) · Nature · doi:10.1038/nature09637 · Cited by 2,510
Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells
Farin, H. F., Van Es, J. H., & Clevers, H. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.08.031 · Cited by 655
Self-citationHaigis, K. M., Kendall, K. R., Wang, Y., Cheung, A., Haigis, M. C., Glickman, J. N., Niwa-Kawakita, M., Sweet-Cordero, A., Sebolt-Leopold, J., Shannon, K. M., et al. (2008) · Nature Genetics · doi:10.1038/ng.115 · Cited by 610
Kozar, S., Morrissey, E., Nicholson, A. M., van der Heijden, M., Zecchini, H. I., Kemp, R., Tavaré, S., Vermeulen, L., & Winton, D. J. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.08.001 · Cited by 214
Cited by
Somatic mutation in cancer and normal cells
Martincorena, I., & Campbell, P. J. (2015) · Science · doi:10.1126/science.aab4082 · Cited by 1,396
Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery
Weeber, F., Ooft, S. N., Dijkstra, K. K., & Voest, E. E. (2017) · Cell Chemical Biology · doi:10.1016/j.chembiol.2017.06.012 · Cited by 486
A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling
Schneider, C., O’Leary, C. E., von Moltke, J., Liang, H.-E., Ang, Q. Y., Turnbaugh, P. J., Radhakrishnan, S., Pellizzon, M., Ma, A., & Locksley, R. M. (2018) · Cell · doi:10.1016/j.cell.2018.05.014 · Cited by 478
Colorectal Cancer Stem Cells: From the Crypt to the Clinic
Zeuner, A., Todaro, M., Stassi, G., & De Maria, R. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.11.012 · Cited by 368
Goodell, M. A., & Rando, T. A. (2015) · Science · doi:10.1126/science.aab3388 · Cited by 347
Metadata
- Authors
- Snippert, H. J., Schepers, A. G., van Es, J. H., Simons, B. D., & Clevers, H.
- Venue
- EMBO reports
- Published
- 2013-12-16
- Volume
- 15
- Issue
- 1
- Pages
- 62-69
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2162756888
- Cited by
- 239
- References
- 4
- FWCI
- 9.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Snippert, H. J., Schepers, A. G., van Es, J. H., Simons, B. D., & Clevers, H. (2014). Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion. EMBO reports. https://doi.org/10.1002/embr.201337799
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
