Stem cells and healthy aging

Signatures of mutational processes in human cancer

Initiative, A. P. C. G., Alexandrov, L. B., ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, PedBrain, I., Nik-Zainal, S., Wedge, D. C., Aparicio, S. A. J. R., Behjati, S., Biankin, A. V., et al. (2013) · Nature · doi:10.1038/nature12477 · Cited by 9,660 · see citing works

Age-related clonal hematopoiesis associated with adverse outcomes

Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841 · see citing works

Mutational landscape and significance across 12 major cancer types

Kandoth, C., McLellan, M. D., Vandin, F., Ye, K., Niu, B., Lu, C., Xie, M., Zhang, Q., McMichael, J. F., Wyczalkowski, M. A., et al. (2013) · Nature · doi:10.1038/nature12634 · Cited by 4,419 · see citing works

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

Genovese, G., Kähler, A. K., Handsaker, R. E., Lindberg, J., Rose, S. A., Bakhoum, S. F., Chambert, K., Mick, E., Neale, B. M., Fromer, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409405 · Cited by 3,531 · see citing works

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287 · see citing works

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087 · see citing works

Understanding the odd science of aging

Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984 · see citing works

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

Snippert, H. J., van der Flier, L. G., Sato, T., van Es, J. H., van den Born, M., Kroon-Veenboer, C., Barker, N., Klein, A. M., van Rheenen, J., Simons, B. D., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.016 · Cited by 1,951 · see citing works

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti, C., & Vogelstein, B. (2015) · Science · doi:10.1126/science.1260825 · Cited by 1,927 · see citing works

Age-related mutations associated with clonal hematopoietic expansion and malignancies

Xie, M., Lu, C., Wang, J., McLellan, M. D., Johnson, K. J., Wendl, M. C., McMichael, J. F., Schmidt, H. K., Yellapantula, V., Miller, C. A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3733 · Cited by 1,874 · see citing works

High burden and pervasive positive selection of somatic mutations in normal human skin

Martincorena, I., Roshan, A., Gerstung, M., Ellis, P., Van Loo, P., McLaren, S., Wedge, D. C., Fullam, A., Alexandrov, L. B., Tubio, J. M., et al. (2015) · Science · doi:10.1126/science.aaa6806 · Cited by 1,770 · see citing works

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763 · see citing works

The origin and evolution of mutations in acute myeloid leukemia

Welch, J. S., Ley, T. J., Link, D. C., Miller, C. A., Larson, D. E., Koboldt, D. C., Wartman, L. D., Lamprecht, T. L., Liu, F., Xia, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.023 · Cited by 1,575 · see citing works

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., & Rando, T. A. (2007) · Science · doi:10.1126/science.1144090 · Cited by 1,564 · see citing works

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

Moran-Crusio, K., Reavie, L., Shih, A., Abdel-Wahab, O., Ndiaye-Lobry, D., Lobry, C., Figueroa, M. E., Vasanthakumar, A., Patel, J., Zhao, X., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.001 · Cited by 1,339 · see citing works

Dnmt3a is essential for hematopoietic stem cell differentiation

Challen, G. A., Sun, D., Jeong, M., Luo, M., Jelinek, J., Berg, J. S., Bock, C., Vasanthakumar, A., Gu, H., Xi, Y., et al. (2012) · Nature Genetics · doi:10.1038/ng.1009 · Cited by 1,122 · see citing works

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

Villeda, S. A., Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., Smith, L. K., Bieri, G., Lin, K., Berdnik, D., et al. (2014) · Nature Medicine · doi:10.1038/nm.3569 · Cited by 1,081 · see citing works

TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

Quivoron, C., Couronné, L., Della Valle, V., Lopez, C. K., Plo, I., Wagner-Ballon, O., Do Cruzeiro, M., Delhommeau, F., Arnulf, B., Stern, M.-H., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.003 · Cited by 924 · see citing works

Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle

Sinha, M., Jang, Y. C., Oh, J., Khong, D., Wu, E. Y., Manohar, R., Miller, C., Regalado, S. G., Loffredo, F. S., Pancoast, J. R., et al. (2014) · Science · doi:10.1126/science.1251152 · Cited by 824 · see citing works

Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal

Sun, D., Luo, M., Jeong, M., Rodriguez, B., Xia, Z., Hannah, R., Wang, H., Le, T., Faull, K. F., Chen, R., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.03.002 · Cited by 686 · see citing works

Intestinal Stem Cell Replacement Follows a Pattern of Neutral Drift

López‐García, C., Klein, A. M., Simons, B. D., & Winton, D. J. (2010) · Science · doi:10.1126/science.1196236 · Cited by 646 · see citing works

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

Ko, M., Bandukwala, H. S., An, J., Lamperti, E. D., Thompson, E. C., Hastie, R., Tsangaratou, A., Rajewsky, K., Koralov, S. B., & Rao, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112317108 · Cited by 616 · see citing works

Widespread and tissue specific age-related DNA methylation changes in mice

Maegawa, S., Hinkal, G., Kim, H. S., Shen, L., Zhang, L., Zhang, J., Zhang, N., Liang, S., Donehower, L. A., & Issa, J.-P. J. (2010) · Genome Research · doi:10.1101/gr.096826.109 · Cited by 553 · see citing works

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Zhang, W., Li, J., Suzuki, K., Qu, J., Wang, P., Zhou, J., Liu, X., Ren, R., Xu, X., Ocampo, A., et al. (2015) · Science · doi:10.1126/science.aaa1356 · Cited by 551 · see citing works

p53 Regulates Hematopoietic Stem Cell Quiescence

Liu, Y., Elf, S. E., Miyata, Y., Sashida, G., Liu, Y., Huang, G., Di Giandomenico, S., Lee, J. M., Deblasio, A., Menendez, S., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2008.11.006 · Cited by 547 · see citing works

Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging

Liu, L., Cheung, T. H., Charville, G. W., Hurgo, B. M. C., Leavitt, T., Shih, J., Brunet, A., & Rando, T. A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.043 · Cited by 544 · see citing works

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

Greer, E. L., Maures, T. J., Hauswirth, A. G., Green, E. M., Leeman, D. S., Maro, G. S., Han, S., Banko, M. R., Gozani, O., & Brunet, A. (2010) · Nature · doi:10.1038/nature09195 · Cited by 543 · see citing works

Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis

McKerrell, T., Park, N., Moreno, T., Grove, C. S., Ponstingl, H., Stephens, J., Crawley, C., Craig, J., Scott, M. A., Hodkinson, C., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.005 · Cited by 534 · see citing works

GDF11 increases with age and inhibits skeletal muscle regeneration

Egerman, M. A., Cadena, S. M., Gilbert, J. A., Meyer, A., Nelson, H. N., Swalley, S. E., Mallozzi, C., Jacobi, C., Jennings, L. L., Clay, I., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.010 · Cited by 527 · see citing works

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

Rando, T. A., & Chang, H. Y. (2012) · Cell · doi:10.1016/j.cell.2012.01.003 · Cited by 520 · see citing works

β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis

Smith, L. K., He, Y., Park, J.-S., Bieri, G., Snethlage, C. E., Lin, K., Gontier, G., Wabl, R., Plambeck, K. E., Udeochu, J., et al. (2015) · Nature Medicine · doi:10.1038/nm.3898 · Cited by 500 · see citing works

Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging

Beerman, I., Bock, C., Garrison, B. S., Smith, Z. D., Gu, H., Meissner, A., & Rossi, D. J. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.017 · Cited by 485 · see citing works

Elevated histone expression promotes life span extension

Feser, J., Truong, D., Das, C., Carson, J. J., Kieft, J., Harkness, T., & Tyler, J. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.015 · Cited by 435 · see citing works

Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration

Elabd, C., Cousin, W., Upadhyayula, P., Chen, R. Y., Chooljian, M. S., Li, J., Kung, S., Jiang, K. P., & Conboy, I. M. (2014) · Nature Communications · doi:10.1038/ncomms5082 · Cited by 411 · see citing works

Defining Stem Cell Dynamics in Models of Intestinal Tumor Initiation

Vermeulen, L., Morrissey, E. R., van der Heijden, M., Nicholson, A. M., Sottoriva, A., Buczacki, S. J. A., Kemp, R., Tavaré, S., & Winton, D. J. (2013) · Science · doi:10.1126/science.1243148 · Cited by 397 · see citing works

Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes

Chen, K., Chen, Z., Wu, D., Zhang, L., Lin, X., Su, J., Rodriguez, B., Xi, Y., Xia, Z., Chen, X., et al. (2015) · Nature Genetics · doi:10.1038/ng.3385 · Cited by 373 · see citing works

Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila

Biteau, B., Karpac, J., Supoyo, S., DeGennaro, M., Lehmann, R., & Jasper, H. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001159 · Cited by 351 · see citing works

Genome sequencing of normal cells reveals developmental lineages and mutational processes

Behjati, S., Huch, M., van Boxtel, R., Karthaus, W., Wedge, D., Tamuri, A. U., Martincorena, I., Petljak, M., Alexandrov, L., Gundem, G., et al. (2014) · Nature · doi:10.1038/nature13448 · Cited by 342 · see citing works

Universal patterns of stem cell fate in cycling adult tissues

Klein, A. M., & Simons, B. D. (2011) · Development · doi:10.1242/dev.060103 · Cited by 329 · see citing works

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

Naito, A. T., Sumida, T., Nomura, S., Liu, M.-L., Higo, T., Nakagawa, A., Okada, K., Sakai, T., Hashimoto, A., Hara, Y., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.047 · Cited by 320 · see citing works

Manifestations and mechanisms of stem cell aging

Liu, L. A., & Rando, T. A. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201010131 · Cited by 306 · see citing works

Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing

Ergen, A. V., Boles, N. C., & Goodell, M. A. (2012) · Blood · doi:10.1182/blood-2011-11-391730 · Cited by 280 · see citing works

The replication rate of human hematopoietic stem cells in vivo

Catlin, S. N., Busque, L., Gale, R. E., Guttorp, P., & Abkowitz, J. L. (2011) · Blood · doi:10.1182/blood-2010-08-303537 · Cited by 259 · see citing works

The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging

Dumble, M. L., Moore, L. M., Chambers, S. M., Geiger, H., Zant, G. E. V., Goodell, M. A., & Donehower, L. A. (2006) · Blood · doi:10.1182/blood-2006-03-010413 · Cited by 241 · see citing works

Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches

Conboy, I. M., & Rando, T. A. (2012) · Cell Cycle · doi:10.4161/cc.20437 · Cited by 239 · see citing works

Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion

Snippert, H. J. G., Schepers, A. G., van Es, J. H., Simons, B. D., & Clevers, H. C. (2013) · EMBO Reports · doi:10.1002/embr.201337799 · Cited by 239 · see citing works

H3K36 methylation promotes longevity by enhancing transcriptional fidelity

Sen, P., Dang, W., Donahue, G., Dai, J., Dorsey, J., Cao, X., Liu, W., Cao, K., Perry, R., Lee, J. Y., et al. (2015) · Genes & Development · doi:10.1101/gad.263707.115 · Cited by 233 · see citing works

Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications

Bonnefond, A., Skrobek, B., Lobbens, S., Eury, E., Thuillier, D., Cauchi, S., Lantieri, O., Balkau, B., Riboli, E., Marre, M., et al. (2013) · Nature Genetics · doi:10.1038/ng.2700 · Cited by 139 · see citing works

Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations

Rozhok, A. I., & DeGregori, J. V. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501713112 · Cited by 115 · see citing works

The Evolution of Dominance

Wright, S. (1929) · The American Naturalist · doi:10.1086/280290 · Cited by 108 · see citing works

Aging as a driver of leukemogenesis

McKerrell, T., & Vassiliou, G. S. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac4428 · Cited by 48 · see citing works

Facing up to the global challenges of ageing

Partridge, L., Deelen, J., & Slagboom, P. E. (2018) · Nature · doi:10.1038/s41586-018-0457-8 · Cited by 1,475 · see citing works

Metabolic Control of Longevity

López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753 · see citing works

Regenerating CNS myelin — from mechanisms to experimental medicines

Franklin, R. J. M., & ffrench-Constant, C. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.136 · Cited by 647 · see citing works

Aging and age‐related diseases: from mechanisms to therapeutic strategies

Li, Z., Zhang, Z., Ren, Y., Wang, Y., Fang, J., Yue, H., Ma, S., & Guan, F. (2021) · Biogerontology · doi:10.1007/s10522-021-09910-5 · Cited by 668 · see citing works

The Aging Cardiovascular System

Paneni, F., Diaz Cañestro, C., Libby, P., Lüscher, T. F., & Camici, G. G. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.01.064 · Cited by 618 · see citing works

Niche stiffness underlies the ageing of central nervous system progenitor cells

Segel, M., Neumann, B., Hill, M. F. E., Weber, I. P., Viscomi, C., Zhao, C., Young, A., Agley, C. C., Thompson, A. J., Gonzalez, G. A., et al. (2019) · Nature · doi:10.1038/s41586-019-1484-9 · Cited by 532 · see citing works

Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing

Lin, H., Sohn, J., Shen, H., Langhans, M. T., & Tuan, R. S. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.06.026 · Cited by 448 · see citing works

Aging of hematopoietic stem cells

de Haan, G., & Lazare, S. S. (2018) · Blood · doi:10.1182/blood-2017-06-746412 · Cited by 432 · see citing works

Aging Hallmarks and the Role of Oxidative Stress

Maldonado, E., Morales, S., Urbina, F., & Solari, A. (2023) · Antioxidants · doi:10.3390/antiox12030651 · Cited by 454 · see citing works

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

He, M., Chiang, H.-H., Luo, H., Zheng, Z., Qiao, Q., Wang, L., Tan, M., Ohkubo, R., Mu, W.-C., Zhao, S., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.009 · Cited by 425 · see citing works

Therapy-related myeloid neoplasms: when genetics and environment collide

McNerney, M. E., Godley, L. A., & Beau, M. M. L. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.60 · Cited by 422 · see citing works

Stem cell competition orchestrates skin homeostasis and ageing

Liu, N., Matsumura, H., Kato, T., Ichinose, S., Takada, A., Namiki, T., Asakawa, K., Morinaga, H., Mohri, Y., De Arcangelis, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1085-7 · Cited by 422 · see citing works

Ageing and rejuvenation of tissue stem cells and their niches

Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00510-w · Cited by 407 · see citing works

Quiescence of Adult Mammalian Neural Stem Cells: A Highly Regulated Rest

Urbán, N., Blomfield, I. M., & Guillemot, F. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.026 · Cited by 370 · see citing works

DNA Damage in Stem Cells

Vitale, I., Manic, G., De Maria, R., Kroemer, G., & Galluzzi, L. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.04.006 · Cited by 361 · see citing works

Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic

Liu, P., Zhao, H., & Luo, Y. (2017) · Aging and Disease · doi:10.14336/ad.2017.0816 · Cited by 348 · see citing works

Healthy aging: The ultimate preventative medicine

Kaeberlein, M., Rabinovitch, P. S., & Martin, G. M. (2015) · Science · doi:10.1126/science.aad3267 · Cited by 341 · see citing works

Caloric restriction delays age-related methylation drift

Maegawa, S., Lu, Y., Tahara, T., Lee, J. T., Madžo, J., Liang, S., Jelı́nek, J., Colman, R. J., & Issa, J. J. (2017) · Nature Communications · doi:10.1038/s41467-017-00607-3 · Cited by 278 · see citing works

The path from mitochondrial <scp>ROS</scp> to aging runs through the mitochondrial permeability transition pore

Rottenberg, H., & Hoek, J. B. (2017) · Aging Cell · doi:10.1111/acel.12650 · Cited by 275 · see citing works

Regulation of Stem Cell Aging by Metabolism and Epigenetics

Ren, R., Ocampo, A., Liu, G., & Belmonte, J. C. I. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.019 · Cited by 269 · see citing works

The Genetics of Aging: A Vertebrate Perspective

Singh, P. P., Demmitt, B. A., Nath, R. D., & Brunet, A. (2019) · Cell · doi:10.1016/j.cell.2019.02.038 · Cited by 259 · see citing works

Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity

de Morrée, A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00568-6 · Cited by 243 · see citing works

Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging

Salzer, M. C., Lafzi, A., Berenguer, A., Youssif, C., Castellanos‐Martín, A., Solanas, G., Peixoto, F. O., Attolini, C. S., Prats, N., Aguilera, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.012 · Cited by 243 · see citing works

Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress

Solanas, G., Peixoto, F. O., Perdiguero, E., Jardı́, M., Ruiz‐Bonilla, V., Datta, D., Symeonidi, A., Castellanos‐Martín, A., Welz, P.-S., Caballero, J. M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.035 · Cited by 229 · see citing works

Effect of aging on stem cells

Ahmed, A. S. I., Sheng, M. H. ‐., Wasnik, S., Baylink, D. J., & Lau, K. ‐. W. (2017) · World Journal of Experimental Medicine · doi:10.5493/wjem.v7.i1.1 · Cited by 202 · see citing works

A mosaic world: puzzles revealed by adult neural stem cell heterogeneity

Chaker, Z., Codega, P., & Doetsch, F. (2016) · WIREs Developmental Biology · doi:10.1002/wdev.248 · Cited by 198 · see citing works

Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases

Song, S., Lam, E. W.-F., Tchkonia, T., Kirkland, J. L., & Sun, Y. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.03.008 · Cited by 195 · see citing works

The aging skin microenvironment dictates stem cell behavior

Ge, Y., Miao, Y., Gur-Cohen, S., Gomez, N., Yang, H., Nikolova, M., Polak, L., Hu, Y., Verma, A., Elemento, O., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901720117 · Cited by 190 · see citing works

Roles and mechanisms of BAP1 deubiquitinase in tumor suppression

Masclef, L., Ahmed, O., Estavoyer, B., Larrivée, B., Labrecque, N., Nijnik, A., & Affar, E. B. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-020-00709-4 · Cited by 184 · see citing works

JAK2V617F-Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure

Sano, S., Wang, Y., Yura, Y., Sano, M., Oshima, K., Yang, Y., Katanasaka, Y., Min, K.-D., Matsuura, S., Ravid, K., et al. (2019) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2019.05.013 · Cited by 170 · see citing works

SIRT3 consolidates heterochromatin and counteracts senescence

Diao, Z., Ji, Q., Wu, Z., Zhang, W., Cai, Y., Wang, Z., Hu, J., Liu, Z., Wang, Q., Bi, S., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab161 · Cited by 171 · see citing works

Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis

Fu, L., Hu, Y., Song, M., Liu, Z., Zhang, W., Yu, F., Wu, J., Wang, S., Belmonte, J. C. I., Chan, P., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000201 · Cited by 164 · see citing works

Somatic Mutations and Clonal Hematopoiesis

Fuster, J. J., & Walsh, K. (2018) · Circulation Research · doi:10.1161/circresaha.117.312115 · Cited by 163 · see citing works

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging

Luo, H., Mu, W.-C., Karki, R., Chiang, H.-H., Mohrin, M., Shin, J. J., Ohkubo, R., Ito, K., Kanneganti, T.-D., & Chen, D. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.101 · Cited by 161 · see citing works

Stem cell quiescence: the challenging path to activation

Urbán, N., & Cheung, T. H. (2021) · Development · doi:10.1242/dev.165084 · Cited by 154 · see citing works

The heterogeneity of mesenchymal stem cells: an important issue to be addressed in cell therapy

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Type XVII collagen coordinates proliferation in the interfollicular epidermis

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