The DOI matches its Crossref record; 210 of the 211 references it cites were found in a registry or an index.
Ubiquitin in the immune system
Open accessAbstract
Ubiquitination is a post-translational modification process that has been implicated in the regulation of innate and adaptive immune responses. There is increasing evidence that both ubiquitination and its reversal, deubiquitination, play crucial roles not only during the development of the immune system but also in the orchestration of an immune response by ensuring the proper functioning of the different cell types that constitute the immune system. Here, we provide an overview of the latest discoveries in this field and discuss how they impact our understanding of the ubiquitin system in host defence mechanisms as well as self-tolerance.
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“This could be controlled by suppressing the development of auto-reactive immune cells through ubiquitination which is a degradative tag to be recognized by a proteasome complex such as PSMD7 (Lodish et al., 2004; Zinngrebe et al., 2014).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Zinngrebe et al., 2014
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Metadata
- Authors
- Zinngrebe, J., Montinaro, A., Peltzer, N., & Walczak, H.
- Affiliations
- University College London (GB)
- Corresponding author
- Walczak, Henning
- Venue
- The EMBO Reports
- Published
- 2013-12-27
- Volume
- 15
- Issue
- 1
- Pages
- 28-45
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- PMC
- PMC4303447
- OpenAlex
- W2147973026
- Cited by
- 227
- References
- 211
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 21 · 2023: 27 · 2022: 21 · 2021: 22 · 2020: 14 · 2019: 14 · 2018: 16 · 2017: 16 · 2016: 25 · 2015: 15 · 2014: 11
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Update notices
- erratum (2014-03-07)
- Open access
- hybrid
- doi.org
- Locations
- EMBO Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Boehringer Ingelheim Fonds
- Swiss National Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- ubiquitination, deubiquitination, ubiquitin system, innate immunity, adaptive immunity, immune system development, host defense, self-tolerance, post-translational modification
- MeSH terms
- Animals, Humans, Immunity, Innate, Tumor Necrosis Factor-alpha, Signal Transduction, Self Tolerance, Ubiquitin, Adaptor Proteins, Signal Transducing, Toll-Like Receptors, Ubiquitination, Host-Pathogen Interactions, Proteolysis
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