Cited by 236Ubiquitin and proteasome pathwaysImmune Response and InflammationNF-κB Signaling Pathways

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Ubiquitin in the immune system

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Zinngrebe, Julia, Montinaro, Antonella, Peltzer, Nieves, Walczak, Henning·2014·The EMBO Reports

DOI 10.1002/embr.201338025PMC PMC4303447

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Abstract

Ubiquitination is a post-translational modification process that has been implicated in the regulation of innate and adaptive immune responses. There is increasing evidence that both ubiquitination and its reversal, deubiquitination, play crucial roles not only during the development of the immune system but also in the orchestration of an immune response by ensuring the proper functioning of the different cell types that constitute the immune system. Here, we provide an overview of the latest discoveries in this field and discuss how they impact our understanding of the ubiquitin system in host defence mechanisms as well as self-tolerance.

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Authors: Zinngrebe, J., Montinaro, A., Peltzer, N., & Walczak, H.
Affiliations: University College London (GB)
Corresponding author: Walczak, Henning
ORCID: Zinngrebe, Julia
Montinaro, Antonella
Peltzer, Nieves
Walczak, Henning
Venue: The EMBO Reports
Publisher: Springer Science and Business Media LLC
Published: 2013-12-27
Volume: 15
Issue: 1
Pages: 28-45
ISSN: 1469-221X (ISSN-L)
1469-3178
DOI: 10.1002/embr.201338025
PMC: PMC4303447
OpenAlex: W2147973026
Cited by: 227
References: 211
Citations by year: 2026: 8 · 2025: 16 · 2024: 21 · 2023: 27 · 2022: 21 · 2021: 22 · 2020: 14 · 2019: 14 · 2018: 16 · 2017: 16 · 2016: 25 · 2015: 15 · 2014: 11
FWCI: 1.60
Type: journal article
Language: en
Update notices: erratum (2014-03-07)
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (tdm)
creativecommons.org/licenses/by/3.0/ (vor)
Locations: EMBO Reports (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Boehringer Ingelheim Fonds
Swiss National Science Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: ubiquitination, deubiquitination, ubiquitin system, innate immunity, adaptive immunity, immune system development, host defense, self-tolerance, post-translational modification
MeSH terms: Animals, Humans, Immunity, Innate, Tumor Necrosis Factor-alpha, Signal Transduction, Self Tolerance, Ubiquitin, Adaptor Proteins, Signal Transducing, Toll-Like Receptors, Ubiquitination, Host-Pathogen Interactions, Proteolysis

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