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Genome‐wide screen identifies signaling pathways that regulate autophagy during Caenorhabditis elegans development

Guo, Bin, Huang, Xinxin, Zhang, Peipei, Qi, Linxiang, Liang, Qianqian, Zhang, Xuebo, Huang, Jie, Fang, Bin, Hou, Wenru, Han, Jinghua, Zhang, Hong·2014·The EMBO Reports

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  1. Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y (2009) Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol 10: 458–467 · DOI
  2. Lamb CA, Yoshimori T, Tooze SA (2013) The autophagosome: origins unknown, biogenesis complex. Nat Rev Mol Cell Biol 14: 759–774 · DOI
  3. Lu Q, Wu F, Zhang H (2013) Aggrephagy: lessons from C. elegans. Biochemical J 452: 381–390 · DOI
  4. Itakura E, Kishi‐Itakura C, Mizushima N (2012) The hairpin‐type tail‐anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell 151: 1256–1269 · DOI
  5. Sengupta S, Peterson TR, Sabatini DM (2010) Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 40: 310–322 · DOI
  6. Russell RC, Yuan HX, Guan KL (2014) Autophagy regulation by nutrient signaling. Cell Res 24: 42–57 · DOI
  7. Lipinski MM, Hoffman G, Ng A, Zhou W, Py BF, Hsu E, Liu X, Eisenberg J, Liu J, Blenis J, et al (2010) A genome‐wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Dev Cell 18: 1041–1052 · DOI
  8. Chauhan S, Goodwin JG, Chauhan S, Manyam G, Wang J, Kamat AM, Boyd DD (2013) ZKSCAN3 is a master transcriptional repressor of autophagy. Mol Cell 50: 16–28 · DOI · Paper page
  9. Tian Y, Li ZP, Hu WQ, Ren HY, Tian E, Zhao Y, Lu Q, Huang XX, Yang PG, Li X, et al (2010) C. elegans screen identifies autophagy genes specific to multicellular organisms. Cell 141: 1042–1055 · DOI · Paper page
  10. Zhang YX, Yan LB, Zhou Z, Yang PG, Tian E, Zhang K, Zhao Y, Li ZP, Song B, Han JH, et al (2009) SEPA‐1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans. Cell 136: 308–321 · DOI
  11. Lin L, Yang PG, Huang XX, Zhang H, Lu Q, Zhang H (2013) The scaffold protein EPG‐7 links cargo‐receptor complexes with the autophagic assembly machinery. J Cell Biol 201: 113–129 · DOI
  12. Zhong W, Sternberg PW (2006) Genome‐wide prediction of C. elegans genetic interactions. Science 311: 1481–1484 · DOI
  13. Savage‐Dunn C (2005) TGF‐beta signaling. WormBook Sep 9: 1–12 · DOI
  14. Wu X, Shi Z, Cui M, Han M, Ruvkun G (2012) Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes. PLoS Genet 8: e1002542 · DOI
  15. Meléndez A, Tallóczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B (2003) Autophagy genes are essential for dauer development and life‐span extension in C. elegans. Science 301: 1387–1391 · DOI · Paper page
  16. Jia K, Chen D, Riddle DL (2004) The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131: 3897–3906 · DOI · Paper page
  17. Cao SS, Kaufman RJ (2012) Unfolded protein response. Curr Biol 22: R622–R626 · DOI
  18. Pellegrino MW, Nargund AM, Haynes CM (2013) Signaling the mitochondrial unfolded protein response. Biochim Biophys Acta 1833: 410–416 · DOI · Paper page
  19. O'Rourke EJ, Ruvkun G (2013) MXL‐3 and HLH‐30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol 15: 668–676 · DOI
  20. Lapierre LR, De Magalhaes Filho CD, McQuary PR, Chu CC, Visvikis O, Chang JT, Gelino S, Ong B, Davis AE, Irazoqui JE, et al (2013) The TFEB orthologue HLH‐30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nat Commun 4: 2267 · DOI · Paper page
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Metadata

Authors
Guo, B., Huang, X., Zhang, P., Qi, L., Liang, Q., Zhang, X., Huang, J., Fang, B., Hou, W., Han, J., & Zhang, H.
Venue
The EMBO Reports
Published
2014-04-24
Volume
15
Issue
6
Pages
705-713
ISSN
  • 1469-221X
  • 1469-3178
Cited by
34
References
4
Language
en
Funders
  • National Basic Research Program of China (2013CB910100, 2011CB910100)
  • NSFC (31225018)
  • International Early Career Scientist
  • Howard Hughes Medical Institute

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