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The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

Jia, Kailiang, Chen, Di, Riddle, Donald L.·2004·Development
DOI 10.1242/dev.01255
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Abstract

The highly conserved target-of-rapamycin (TOR) protein kinases control cell growth in response to nutrients and growth factors. In mammals, TOR has been shown to interact with raptor to relay nutrient signals to downstream translation machinery. We report that in C. elegans, mutations in the genes encoding CeTOR and raptor result in dauer-like larval arrest, implying that CeTOR regulates dauer diapause. The daf-15 (raptor) and let-363 (CeTOR) mutants shift metabolism to accumulate fat, and raptor mutations extend adult life span. daf-15 transcription is regulated by DAF-16, a FOXO transcription factor that is in turn regulated by daf-2 insulin/IGF signaling. This is a new mechanism that regulates the TOR pathway. Thus, DAF-2 insulin/IGF signaling and nutrient signaling converge on DAF-15 (raptor) to regulate C. elegans larval development, metabolism and life span.

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  • Genetic or pharmacological inhibition of TOR signalling extends lifespan in invertebrates including yeast, nematodes and fruit flies.

    “Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruit flies1–5.”

    From Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) · cites this paper as [3]

  • Initial evidence that reduced TOR function can extend longevity came primarily from studies in yeast and invertebrates.

    “Initial evidence that reduced TOR function can extend longevity came primarily from studies in yeast1,2 and invertebrates3–5.”

    From Rapamycin fed late in life extends lifespan in genetically heterogeneous mice (2009) · cites this paper as [3]

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Metadata

Authors
Jia, K., Chen, D., & Riddle, D. L.
Affiliations
Molecular Biology Program and Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
Venue
Development
Publisher
The Company of Biologists
Published
2004-08-15
Volume
131
Issue
16
Pages
3897-3906
ISSN
  • 1477-9129
  • 0950-1991
DOI
10.1242/dev.01255
Cited by
615
References
3
Language
en

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