Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605 · see citing works

Autophagy as a regulated pathway of cellular degradation.

Klionsky, D., & Emr, S. (2000) · Science · doi:10.1126/science.290.5497.1717 · Cited by 3,794 · see citing works

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

Sulston, J. E., & Horvitz, H. R. (1977) · Developmental Biology · doi:10.1016/0012-1606(77)90158-0 · Cited by 3,479 · see citing works

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347 · see citing works

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250 · see citing works

Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae

Tsukada, M., & Ohsumi, Y. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80398-e · Cited by 1,756 · see citing works

Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells

Petiot, A., Ogier‐Denis, É., Blommaart, E. F. C., Meijer, A. J., & Codogno, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.992 · Cited by 1,168 · see citing works

The pre‐autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

Suzuki, K., Kirisako, T., Kamada, Y., Mizushima, N., Noda, T., & Ohsumi, Y. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.5971 · Cited by 1,034 · see citing works

Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting in <i>Saccharomyces cerevisiae</i>

Kihara, A., Noda, T., Ishihara, N., & Ohsumi, Y. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.3.519 · Cited by 1,004 · see citing works

Formation Process of Autophagosome Is Traced with Apg8/Aut7p in Yeast

Kirisako, T., Baba, M., Ishihara, N., Miyazawa, K., Ohsumi, M., Yoshimori, T., Noda, T., & Ohsumi, Y. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.435 · Cited by 881 · see citing works

Beclin–phosphatidylinositol 3‐kinase complex functions at the trans‐Golgi network

Kihara, A., Kabeya, Y., Ohsumi, Y., & Yoshimori, T. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve061 · Cited by 813 · see citing works

Two Pleiotropic Classes of daf-2 Mutation Affect Larval Arrest, Adult Behavior, Reproduction and Longevity in Caenorhabditis elegans

Gems, D., Sutton, A. J., Sundermeyer, M. L., Albert, P. S., King, K. V., Edgley, M. L., Larsen, P. L., & Riddle, D. L. (1998) · Genetics · doi:10.1093/genetics/150.1.129 · Cited by 718 · see citing works

The APG8/12-activating Enzyme APG7 Is Required for Proper Nutrient Recycling and Senescence in Arabidopsis thaliana

Doelling, J. H., Walker, J. M., Friedman, E. M., Thompson, A. R., & Vierstra, R. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204630200 · Cited by 599 · see citing works

Leaf Senescence and Starvation-Induced Chlorosis Are Accelerated by the Disruption of an Arabidopsis Autophagy Gene

Hanaoka, H., Noda, T., Shirano, Y., Kato, T., Hayashi, H., Shibata, D., Tabata, S., & Ohsumi, Y. (2002) · PLANT PHYSIOLOGY · doi:10.1104/pp.011024 · Cited by 595 · see citing works

The Tumor Suppressor PTEN Positively Regulates Macroautophagy by Inhibiting the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway

Arico, S., Petiot, A., Bauvy, C., Dubbelhuis, P. F., Meijer, A. J., Codogno, P., & Ogier‐Denis, É. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100319200 · Cited by 576 · see citing works

Autophagy and related mechanisms of lysosome-mediated protein degradation

Dunn, W. A. (1994) · Trends in Cell Biology · doi:10.1016/0962-8924(94)90069-8 · Cited by 523 · see citing works

Interacting genes in nematode dauer larva formation

Riddle, D. L., Swanson, M. M., & Albert, P. S. (1981) · Nature · doi:10.1038/290668a0 · Cited by 518 · see citing works

Convergence of Multiple Autophagy and Cytoplasm to Vacuole Targeting Components to a Perivacuolar Membrane Compartment Prior tode Novo Vesicle Formation

Kim, J., Huang, W.-P., Stromhaug, P. E., & Klionsky, D. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109134200 · Cited by 272 · see citing works

The Itinerary of a Vesicle Component, Aut7p/Cvt5p, Terminates in the Yeast Vacuole via the Autophagy/Cvt Pathways

Huang, W.-P., Scott, S. V., Kim, J., & Klionsky, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.5845 · Cited by 241 · see citing works

Macroautophagy Is Required for Multicellular Development of the Social Amoeba Dictyostelium discoideum

Otto, G. P., Wu, M. Y., Kazgan, N., Anderson, O. R., & Kessin, R. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212467200 · Cited by 221 · see citing works

Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase.Preprint

Ogura, K., Wicky, C., Magnenat, L., Tobler, H., Mori, I., Müller, F., & Ohshima, Y. (1994) · Genes & Development · doi:10.1101/gad.8.20.2389 · Cited by 165 · see citing works

Mutants of Caenorhabditis elegans that form dauer-like larvae

Albert, P. S., & Riddle, D. L. (1988) · Developmental Biology · doi:10.1016/0012-1606(88)90138-8 · Cited by 146 · see citing works

Functional genomics Double-stranded RNA poses puzzle

Wagner, R. W., & Sun, L. (1998) · Nature · doi:10.1038/35750 · Cited by 130 · see citing works

A gene affecting production of the Caenorhabditis elegans dauer-inducing pheromone

Golden, J. W., & Riddle, D. L. (1985) · Molecular and General Genetics MGG · doi:10.1007/bf00332953 · Cited by 103 · see citing works

Heterochronic genes control the stage-specific initiation and expression of the dauer larva developmental program in Caenorhabditis elegans.Preprint

Liu, Z., & Ambros, V. (1989) · Genes & Development · doi:10.1101/gad.3.12b.2039 · Cited by 57 · see citing works

Temperature dependence of protein degradation, autophagic sequestration and mitochondrial sugar uptake in rat hepatocytes

Gordon, P. B., Kovács, A. L., & Seglen, P. O. (1987) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(87)90167-4 · Cited by 32 · see citing works

Towards an understanding of the anti-aging mechanism of dietary restriction: A signal transduction theory of aging

Bergamini, E., & Gori, Z. (1995) · Aging Clinical and Experimental Research · doi:10.1007/bf03324374 · Cited by 25 · see citing works

Autophagy in the Pathogenesis of Disease

Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894 · see citing works

Methods in Mammalian Autophagy Research

Mizushima, N., Yoshimori, T., & Levine, B. (2010) · Cell · doi:10.1016/j.cell.2010.01.028 · Cited by 4,497 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996 · see citing works

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500 · see citing works

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Wallace, D. C. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095751 · Cited by 3,185 · see citing works

The role of autophagy during the early neonatal starvation period

Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., & Mizushima, N. (2004) · Nature · doi:10.1038/nature03029 · Cited by 2,865 · see citing works

The genetics of ageing

Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) ¹

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,622 · see citing works

Autophagy in Human Health and Disease

Choi, A. M. K., Ryter, S. W., & Levine, B. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1205406 · Cited by 2,583 · see citing works

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600 · see citing works

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20039 · Cited by 2,311 · see citing works

Autophagy and Aging

Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works

mTOR regulation of autophagy

Jung, C. H., Ro, S.-H., Cao, J., Otto, N. M., & Kim, D.-H. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.017 · Cited by 2,090 · see citing works

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

Jung, C. H., Jun, C. B., Ro, S.-H., Kim, Y.-M., Otto, N. M., Cao, J., Kundu, M., & Kim, D.-H. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1249 · Cited by 2,025 · see citing works

FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953 · see citing works

Role of autophagy in cancer

Mathew, R., Karantza-Wadsworth, V., & White, E. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2254 · Cited by 1,798 · see citing works

Molecular definitions of autophagy and related processes

Galluzzi, L., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cecconi, F., Choi, A. M., Chu, C. T., Codogno, P., Colombo, M. I., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201796697 · Cited by 1,646 · see citing works

Induction of autophagy by spermidine promotes longevity

Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., Ring, J., Schroeder, S., Magnes, C., Antonacci, L., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1975 · Cited by 1,680 · see citing works

Autophagy in mammalian development and differentiation

Mizushima, N., & Levine, B. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-823 · Cited by 1,555 · see citing works

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.

Zhao, J., Brault, J. J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.004 · Cited by 1,489 · see citing works

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

Lum, J. J., Bauer, D. E., Kong, M., Harris, M. H., Li, C., Lindsten, T., & Thompson, C. B. (2005) · Cell · doi:10.1016/j.cell.2004.11.046 · Cited by 1,487 · see citing works

Crosstalk between apoptosis.; necrosis and autophagy

Nikoletopoulou, V., Markaki, M., Palikaras, K., & Tavernarakis, N. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.001 · Cited by 1,366 · see citing works

Neural mechanisms of ageing and cognitive decline

Bishop, N. A., Lu, T., & Yankner, B. A. (2010) · Nature · doi:10.1038/nature08983 · Cited by 1,323 · see citing works

Autophagy in healthy aging and disease

Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00098-4 · Cited by 1,313 · see citing works

The plasticity of aging: insights from long-lived mutants

Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338 · see citing works

Mitochondria and the Autophagy–Inflammation–Cell Death Axis in Organismal Aging

Green, D. R., Galluzzi, L., & Kroemer, G. (2011) · Science · doi:10.1126/science.1201940 · Cited by 1,245 · see citing works

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., Williams, E. G., Jha, P., Lo Sasso, G., Huzard, D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4132 · Cited by 1,105 · see citing works

The role of the Atg1/ULK1 complex in autophagy regulation

Mizushima, N. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.004 · Cited by 1,062 · see citing works

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster

Bjedov, I., Toivonen, J. M., Kerr, F., Slack, C., Jacobson, J., Foley, A., & Partridge, L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.11.010 · Cited by 1,057 · see citing works

Mitophagy: mechanisms, pathophysiological roles, and analysis

Ding, W.-X., & Yin, X.-M. (2012) · bchm · doi:10.1515/hsz-2012-0119 · Cited by 1,032 · see citing works

The common biology of cancer and ageing

Finkel, T., Serrano, M., & Blasco, M. A. (2007) · Nature · doi:10.1038/nature05985 · Cited by 988 · see citing works

Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

Yu, W. H., Cuervo, A. M., Kumar, A., Peterhoff, C. M., Schmidt, S. D., Lee, J.-H., Mohan, P. S., Mercken, M., Farmery, M. R., Tjernberg, L. O., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505082 · Cited by 967 · see citing works

An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations

Kregel, K. C., & Zhang, H. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2006 · Cited by 883 · see citing works

AMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network

Salminen, A., & Kaarniranta, K. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.005 · Cited by 860 · see citing works

HSV-1 ICP34.5 Confers Neurovirulence by Targeting the Beclin 1 Autophagy Protein

Orvedahl, A., Alexander, D., Tallóczy, Z., Sun, Q., Wei, Y., Zhang, W., Burns, D., Leib, D. A., & Levine, B. (2007) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2006.12.001 · Cited by 857 · see citing works

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

Galluzzi, L., Bravo-San Pedro, J. M., Levine, B., Green, D. R., & Kroemer, G. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.22 · Cited by 842 · see citing works

Autophagy and aging: The importance of maintaining "clean" cells

Cuervo, A. M., Bergamini, E., Brunk, U. T., Dröge, W., Ffrench, M., & Terman, A. (2005) · Autophagy · doi:10.4161/auto.1.3.2017 · Cited by 792 · see citing works

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

Palikaras, K., Lionaki, E., & Tavernarakis, N. (2015) · Nature · doi:10.1038/nature14300 · Cited by 770 · see citing works

Autophagy as a promoter of longevity: insights from model organisms

Hansen, M., Rubinsztein, D. C., & Walker, D. W. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0033-y · Cited by 754 · see citing works

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

Hansen, M., Chandra, A., Mitic, L. L., Onken, B., Driscoll, M., & Kenyon, C. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040024 · Cited by 766 · see citing works

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

Simonsen, A., Cumming, R. C., Brech, A., Isakson, P., Schubert, D. R., & Finley, K. D. (2008) · Autophagy · doi:10.4161/auto.5269 · Cited by 716 · see citing works

Overexpression of Atg5 in mice activates autophagy and extends lifespan

Pyo, J.-O., Yoo, S.-M., Ahn, H.-H., Nah, J., Hong, S.-H., Kam, T.-I., Jung, S., & Jung, Y.-K. (2013) · Nature Communications · doi:10.1038/ncomms3300 · Cited by 721 · see citing works

A brief history of autophagy from cell biology to physiology and disease

Mizushima, N. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0092-5 · Cited by 696 · see citing works

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

Robida-Stubbs, S., Glover-Cutter, K., Lamming, D. W., Mizunuma, M., Narasimhan, S. D., Neumann-Haefelin, E., Sabatini, D. M., & Blackwell, T. K. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.007 · Cited by 648 · see citing works

Widespread protein aggregation as an inherent part of aging in C. elegans

David, D. C., Ollikainen, N., Trinidad, J. C., Cary, M. P., Burlingame, A. L., & Kenyon, C. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000450 · Cited by 627 · see citing works

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

Fernández, Á. F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K. L., He, C., Ting, T., Liu, Y., Chiang, W.-C., et al. (2018) · Nature · doi:10.1038/s41586-018-0162-7 · Cited by 630 · see citing works

Interventions to slow aging in humans: are we ready?

Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell · doi:10.1111/acel.12338 · Cited by 592 · see citing works

Aging as an event of proteostasis collapse

Taylor, R. C., & Dillin, A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004440 · Cited by 538 · see citing works

LC3, an Autophagosome Marker, Can be Incorporated into Protein Aggregates Independent of Autophagy: Caution in the Interpretation of LC3 Localization

Kuma, A., Matsui, M., & Mizushima, N. (2007) · Autophagy · doi:10.4161/auto.4012 · Cited by 555 · see citing works

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

Gamerdinger, M., Hajieva, P., Kaya, A. M., Wolfrum, U., Hartl, F. U., & Behl, C. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.29 · Cited by 522 · see citing works

AMPK at the Nexus of Energetics and Aging

Burkewitz, K., Zhang, Y., & Mair, W. B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.002 · Cited by 483 · see citing works

Oxidative stress and aberrant signaling in aging and cognitive decline

Dröge, W., & Schipper, H. M. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00294.x · Cited by 479 · see citing works

Sirtuins, a promising target in slowing down the ageing process

Grabowska, W., Sikora, E., & Bielak-Zmijewska, A. (2017) · Biogerontology · doi:10.1007/s10522-017-9685-9 · Cited by 470 · see citing works

Protein Homeostasis and Aging: the importance of exquisite quality control

Koga, H., Kaushik, S., & Cuervo, A. M. (2011) · Ageing research reviews · doi:10.1016/j.arr.2010.02.001 · Cited by 476 · see citing works

Essential role for autophagy in life span extension

Madeo, F., Zimmermann, A., Maiuri, M. C., & Kroemer, G. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73946 · Cited by 464 · see citing works

Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging

Carnio, S., LoVerso, F., Baraibar, M. A., Longa, E., Khan, M. M., Maffei, M., Reischl, M., Canepari, M., Loefler, S., Kern, H., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.061 · Cited by 423 · see citing works

Autophagy and the cell biology of age-related disease

Leidal, A. M., Levine, B., & Debnath, J. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0235-8 · Cited by 424 · see citing works

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

Vilchez, D., Morantte, I., Liu, Z., Douglas, P. M., Merkwirth, C., Rodrigues, A. P. C., Manning, G., & Dillin, A. (2012) · Nature · doi:10.1038/nature11315 · Cited by 413 · see citing works

Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans

Lapierre, L. R., Gelino, S., Meléndez, A., & Hansen, M. (2011) · Current Biology · doi:10.1016/j.cub.2011.07.042 · Cited by 343 · see citing works

Autophagy is Required for Dietary Restriction-Mediated Life Span Extension in<i>C. elegans</i>

Jia, K., & Levine, B. (2007) · Autophagy · doi:10.4161/auto.4989 · Cited by 341 · see citing works

Lessons from C. elegans: signaling pathways for longevity

Lapierre, L. R., & Hansen, M. (2012) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2012.07.007 · Cited by 331 · see citing works

The metabolic regulation of aging

Finkel, T. (2015) · Nature Medicine · doi:10.1038/nm.3998 · Cited by 325 · see citing works

Small nucleoli are a cellular hallmark of longevity

Tiku, V., Jain, C., Raz, Y., Nakamura, S., Heestand, B., Liu, W., Späth, M., Suchiman, H. E. D., Müller, R.-U., Slagboom, P. E., et al. (2017) · Nature Communications · doi:10.1038/ncomms16083 · Cited by 287 · see citing works

Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis

Lenoir, O., Jasiek, M., Hénique, C., Guyonnet, L., Hartleben, B., Bork, T., Chipont, A., Flosseau, K., Bensaada, I., Schmitt, A., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1049799 · Cited by 296 · see citing works

Autophagy and the hallmarks of aging

Kaushik, S., Tasset, I., Arias, E., Pampliega, O., Wong, E., Martinez-Vicente, M., & Cuervo, A. M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101468 · Cited by 285 · see citing works

Regulation of the aging process by autophagy.

Salminen, A., & Kaarniranta, K. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.03.004 · Cited by 270 · see citing works

Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging

Leduc-Gaudet, J.-P., Hussain, S. N. A., Barreiro, E., & Gouspillou, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158179 · Cited by 268 · see citing works

Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts

Kang, H. T., Lee, K. B., Kim, S. Y., Choi, H. R., & Park, S. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023367 · Cited by 254 · see citing works

Recent developments in yeast aging

Kaeberlein, M., Burtner, C. R., & Kennedy, B. K. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030084 · Cited by 239 · see citing works

Autophagy in Cardiovascular Aging

Abdellatif, M., Sedej, S., Carmona-Gutierrez, D., Madeo, F., & Kroemer, G. (2018) · Circulation Research · doi:10.1161/circresaha.118.312208 · Cited by 239 · see citing works

Insulin/IGF-like signalling, the central nervous system and aging

Broughton, S., & Partridge, L. (2009) · Biochemical Journal · doi:10.1042/bj20082102 · Cited by 228 · see citing works

KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses

Stavoe, A. K. H., Kargbo-Hill, S. E., Hall, D. H., & Colón-Ramos, D. A. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.06.012 · Cited by 211 · see citing works

Mutations in Fis1 disrupt orderly disposal of defective mitochondria

Shen, Q., Yamano, K., Head, B. P., Kawajiri, S., Cheung, J. T. M., Wang, C., Cho, J.-H., Hattori, N., Youle, R. J., & van der Bliek, A. M. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-09-0525 · Cited by 209 · see citing works

Iron-starvation-induced mitophagy mediates lifespan extension upon mitochondrial stress in C.elegans

Schiavi, A., Maglioni, S., Palikaras, K., Shaik, A., Strappazzon, F., Brinkmann, V., Torgovnick, A., Castelein, N., De Henau, S., Braeckman, B. P., et al. (2015) · Current Biology · doi:10.1016/j.cub.2015.05.059 · Cited by 209 · see citing works

Suppression of autophagic activity by Rubicon is a signature of aging

Nakamura, S., Oba, M., Suzuki, M., Takahashi, A., Yamamuro, T., Fujiwara, M., Ikenaka, K., Minami, S., Tabata, N., Yamamoto, K., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08729-6 · Cited by 205 · see citing works

The Autophagy Lysosomal Pathway and Neurodegeneration

Finkbeiner, S. (2020) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a033993 · Cited by 196 · see citing works

Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.11.004 · Cited by 173 · see citing works

Presynaptic Terminals Independently Regulate Synaptic Clustering and Autophagy of GABA_AReceptors in<i>Caenorhabditis elegans</i>

Rowland, A. M., Richmond, J. E., Olsen, J. G., Hall, D. H., & Bamber, B. A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2279-05.2006 · Cited by 159 · see citing works

Metabolic Activity Determines Efficacy of Macroautophagic Clearance of Pathological Oligomeric α-Synuclein

Yu, W. H., Dorado, B., Figueroa, H. Y., Wang, L., Planel, E., Cookson, M. R., Clark, L. N., & Duff, K. E. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080928 · Cited by 155 · see citing works

Autophagy in animal development

Allen, E. A., & Baehrecke, E. H. (2020) · Cell Death &amp; Differentiation · doi:10.1038/s41418-020-0497-0 · Cited by 127 · see citing works

The effects of p53 on whole organism longevity are mediated by autophagy

Tavernarakis, N., Pasparaki, A., Tasdemir, E., Maiuri, M. C., & Kroemer, G. (2008) · Autophagy · doi:10.4161/auto.6730 · Cited by 132 · see citing works

Ageing and the regulation of protein synthesis: a balancing act?

Tavernarakis, N. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.02.004 · Cited by 129 · see citing works

<scp>TOR</scp>‐mediated regulation of metabolism in aging

Antikainen, H., Driscoll, M., Haspel, G., & Dobrowolski, R. (2017) · Aging Cell · doi:10.1111/acel.12689 · Cited by 122 · see citing works

Autophagy and the immune function in aging

Cuervo, A. M., & Macian, F. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.05.006 · Cited by 112 · see citing works

IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease

Sadagurski, M., Cheng, Z., Rozzo, A., Palazzolo, I., Kelley, G. R., Dong, X., Krainc, D., & White, M. F. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46305 · Cited by 107 · see citing works

Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk

Cassidy, L. D., Young, A. R. J., Young, C. N. J., Soilleux, E. J., Fielder, E., Weigand, B. M., Lagnado, A., Brais, R., Ktistakis, N. T., Wiggins, K. A., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14187-x · Cited by 108 · see citing works

Eaten alive: novel insights into autophagy from multicellular model systems

Zhang, H., & Baehrecke, E. H. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.03.001 · Cited by 102 · see citing works

Autophagic response to exercise training in skeletal muscle with age

Kim, Y. A., Kim, Y. S., Oh, S. L., Kim, H.-J., & Song, W. (2013) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-013-0246-7 · Cited by 108 · see citing works

Downregulation of dynamin-related protein 1 contributes to impaired autophagic flux and angiogenic function in senescent endothelial cells

Lin, J.-R., Shen, W.-L., Yan, C., & Gao, P.-J. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305706 · Cited by 97 · see citing works

The mitochondrial permeability transition: Nexus of aging, disease and longevity

Rottenberg, H., & Hoek, J. B. (2021) · Cells · doi:10.3390/cells10010079 · Cited by 94 · see citing works

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity

Ma, S., Upneja, A., Galecki, A., Tsai, Y.-M., Burant, C. F., Raskind, S., Zhang, Q., Zhang, Z. D., Seluanov, A., Gorbunova, V., et al. (2016) · eLife · doi:10.7554/elife.19130 · Cited by 89 · see citing works

Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons

Stavoe, A. K., Gopal, P. P., Gubas, A., Tooze, S. A., & Holzbaur, E. L. (2019) · eLife · doi:10.7554/elife.44219 · Cited by 82 · see citing works

The Journey of the Synaptic Autophagosome: A Cell Biological Perspective

Kargbo-Hill, S. E., & Colón-Ramos, D. A. (2020) · Neuron · doi:10.1016/j.neuron.2020.01.018 · Cited by 72 · see citing works

Neural ageing and synaptic plasticity: prioritizing brain health in healthy longevity

Navakkode, S., & Kennedy, B. K. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1428244 · Cited by 75 · see citing works

SNF4Aγ, the Drosophila AMPK γ subunit is required for regulation of developmental and stress-induced autophagy

Lippai, M., Csikós, G., Maróy, P., Lukácsovich, T., Juhász, G., & Sass, M. (2008) · Autophagy · doi:10.4161/auto.5719 · Cited by 56 · see citing works

Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders

Evangelisti, C., Cenni, V., & Lattanzi, G. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12928 · Cited by 53 · see citing works

Regulation of mRNA Translation as a Conserved Mechanism of Longevity Control

Mehta, R., Chandler-Brown, D., Ramos, F. J., Shamieh, L. S., & Kaeberlein, M. (2010) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4419-7002-2_2 · Cited by 44 · see citing works

Caloric restriction: implications for sarcopenia and potential mechanisms

Xie, W.-Q., Xiao, W.-F., Tang, K., Wu, Y.-X., Hu, P.-W., Li, Y.-S., Duan, Y., & Lv, S. (2020) · Aging · doi:10.18632/aging.103987 · Cited by 46 · see citing works

T cell receptor-mediated activation is a potent inducer of macroautophagy in human CD8(+)CD28(+) T cells but not in CD8(+)CD28(-) T cells

Arnold, C. R., Pritz, T., Brunner, S., Knabb, C., Salvenmoser, W., Holzwarth, B., Thedieck, K., & Grubeck-Loebenstein, B. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.018 · Cited by 42 · see citing works

Working with Worms: Caenorhabditis elegans as a Model Organism

Meneely, P., Dahlberg, C. L., & Rose, J. K. (2019) · Current Protocols Essential Laboratory Techniques · doi:10.1002/cpet.35 · Cited by 117 · see citing works

Why do more scientists use Caenorhabditis elegans as a model organism to study human system?

Nilwarangkoon, S. (2008) · Journal of Medicine and Health Sciences · doi:10.14456/jmhs.2008.4

Organelle morphogenesis by active membrane remodeling.

Ramakrishnan, N., Ipsen, J., Rao, M., & Kumar, P. B. S. (2015) · Soft Matter · doi:10.1039/c4sm02311k · Cited by 24 · see citing works

The intertwining between lead and ethanol in the model organism Caenorhabditis elegans

Albrecht, P. A., Fernandez-Hubeid, L. E., Deza-Ponzio, R., et al. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.991787 · Cited by 4 · see citing works

Caenorhabditis elegans as a Model Organism to Evaluate the Antioxidant Effects of Phytochemicals

Ayuda‐Durán, B., González‐Manzano, S., Paramás, A. M. G., & Santos‐Buelga, C. (2020) · Molecules · doi:10.3390/molecules25143194 · Cited by 70 · see citing works