The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Jamming bacterial communication: New approaches for the treatment of infectious diseases
Open accessAbstract
The global rise of anti-microbial resistance, combined with the rapid rate of microbial evolution, and the slower development of novel antibiotics, underscores the urgent need for innovative therapeutics. We are facing a post-antibiotic era with a decreased armamentarium to combat infectious diseases. Development of novel drugs will rely on basic research aimed to increase our understanding of bacterial pathogenesis and the inter-cellular chemical signalling among bacterial cells. Such basic science, when combined with contemporary drug discovery technologies, may be translated into therapeutic applications to combat bacterial infections. In this review, we discuss many strategies aimed to interfere with bacterial cell-to-cell signalling via the quorum-sensing (QS) pathway to inhibit bacterial virulence and/or the development of microbial communities (known as biofilms), which are refractory to antibiotic treatment. QS antagonists should be viewed as blockers of pathogenicity rather than as anti-microbials and because QS is not involved in bacterial growth, inhibition of QS should not yield a strong selective pressure for development of resistance. QS inhibitors (QSIs) hold great expectations and we look forward to their application in fighting bacterial infections.
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Cites
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Environmental genome shotgun sequencing of the sargasso sea
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Self-citationPotential application of gaseous nitric oxide as a topical antimicrobial agent
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Background
Cited by
A brief history of the antibiotic era: lessons learned and challenges for the future
Aminov, R. I. (2010) · Frontiers in Microbiology · doi:10.3389/fmicb.2010.00134 · Cited by 1,628
Combating Multidrug‐Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials
O'Connell, K. M. G., Hodgkinson, J. T., Sore, H. F., Welch, M., Salmond, G. P. C., & Spring, D. R. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201209979 · Cited by 435
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Vandeputte, O. M., Kiendrebeogo, M., Rasamiravaka, T., Stévigny, C., Duez, P., Rajaonson, S., Diallo, B., Mol, A., Baucher, M., & El Jaziri, M. (2011) · Microbiology · doi:10.1099/mic.0.049338-0 · Cited by 293
The road to ruin: the formation of disease‐associated oral biofilms
Jakubovics, N., & Kolenbrander, P. (2010) · Oral Diseases · doi:10.1111/j.1601-0825.2010.01701.x · Cited by 198
Metadata
- Authors
- Njoroge, J., & Sperandio, V.
- Venue
- EMBO Molecular Medicine
- Published
- 2009-07
- Volume
- 1
- Issue
- 4
- Pages
- 201-210
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- OpenAlex
- W2104537952
- Cited by
- 206
- References
- 5
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
