The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Predicted-no-effect concentrations for the steroid estrogens estrone, 17β-estradiol, estriol, and 17α-ethinylestradiol
Abstract
The authors derive predicted-no-effect concentrations (PNECs) for the steroid estrogens (estrone [E1], 17β-estradiol [E2], estriol [E3], and 17α-ethinylestradiol [EE2]) appropriate for use in risk assessment of aquatic organisms. In a previous study, they developed a PNEC of 0.35 ng/L for EE2 from a species sensitivity distribution (SSD) based on all available chronic aquatic toxicity data. The present study updates that PNEC using recently published data to derive a PNEC of 0.1 ng/L for EE2. For E2, fish were the most sensitive taxa, and chronic reproductive effects were the most sensitive endpoint. Using the SSD methodology, we derived a PNEC of 2 ng/L for E2. Insufficient data were available to construct an SSD for E1 or E3. Therefore, the authors used in vivo vitellogenin (VTG) induction studies to determine the relative potency of the steroid estrogens to induce VTG. Based on the relative differences between in vivo VTG induction, they derive PNECs of 6 and 60 ng/L for E1 and E3, respectively. Thus, for long-term exposures to steroid estrogens in surface water (i.e., >60 d), the PNECs are 6, 2, 60, and 0.1 ng/L for E1, E2, E3, and EE2, respectively. Higher PNECs are recommended for short-term (i.e., a few days or weeks) exposures. Environ. Toxicol. Chem. 2012;31:1396–1406. © 2012 SETAC
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Water Analysis: Emerging Contaminants and Current Issues
Richardson, S. D., & Ternes, T. A. (2014) · Analytical Chemistry · doi:10.1021/ac500508t · Cited by 2,144
Collapse of a fish population after exposure to a synthetic estrogen
Kidd, K. A., Blanchfield, P. J., Mills, K. H., Palace, V. P., Evans, R. E., Lazorchak, J. M., & Flick, R. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609568104 · Cited by 2,094
Routledge, E. J., & Sumpter, J. P. (1996) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620150303 · Cited by 1,504
Self-citationNash, J. P., Kime, D. E., Van der Ven, L. T. M., Wester, P. W., Brion, F., Maack, G., Stahlschmidt-Allner, P., & Tyler, C. R. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7209 · Cited by 664
Länge, R., Hutchinson, T. H., Croudace, C. P., Siegmund, F., Schweinfurth, H., Hampe, P., Panter, G. H., & Sumpter, J. P. (2001) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620200610 · Cited by 649
Self-citationAlonso-Magdalena, P., Morimoto, S., Ripoll, C., Fuentes, E., & Nadal, A. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8451 · Cited by 632
Jobling, S., Williams, R., Johnson, A., Taylor, A., Gross-Sorokin, M., Nolan, M., Tyler, C. R., van Aerle, R., Santos, E., & Brighty, G. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8050 · Cited by 566
Metcalfe, C. D., Metcalfe, T. L., Kiparissis, Y., Koenig, B. G., Khan, C., Hughes, R. J., Croley, T. R., March, R. E., & Potter, T. (2001) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620200210 · Cited by 559
Mills, L. J., & Chichester, C. (2005) · Science of The Total Environment · doi:10.1016/j.scitotenv.2004.12.070 · Cited by 532
Cited by
Pharmaceuticals in the environment-global occurrences and perspectives
aus der Beek, T., Weber, F.-A., Bergmann, A., Hickmann, S., Ebert, I., Hein, A., & Küster, A. (2015) · Environmental Toxicology and Chemistry · doi:10.1002/etc.3339 · Cited by 1,595
Direct and Indirect Responses of a Freshwater Food Web to a Potent Synthetic Oestrogen
Kidd, K. A., Paterson, M. J., Rennie, M. D., Podemski, C. L., Findlay, D. L., Blanchfield, P. J., & Liber, K. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0578 · Cited by 189
Metadata
- Authors
- Caldwell, D. J., Mastrocco, F., Anderson, P. D., Länge, R., & Sumpter, J. P.
- Venue
- Environmental Toxicology and Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-04-05
- Volume
- 31
- Issue
- 6
- Pages
- 1396-1406
- ISSN
- 0730-7268 (ISSN-L)
- 1552-8618
- OpenAlex
- W2069157996
- Cited by
- 373
- References
- 54
- FWCI
- 17.59
- Type
- journal article
- Language
- en
- Open access
- closed
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