The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Predicted-no-effect concentrations for the steroid estrogens estrone, 17β-estradiol, estriol, and 17α-ethinylestradiol
Abstract
The authors derive predicted-no-effect concentrations (PNECs) for the steroid estrogens (estrone [E1], 17β-estradiol [E2], estriol [E3], and 17α-ethinylestradiol [EE2]) appropriate for use in risk assessment of aquatic organisms. In a previous study, they developed a PNEC of 0.35 ng/L for EE2 from a species sensitivity distribution (SSD) based on all available chronic aquatic toxicity data. The present study updates that PNEC using recently published data to derive a PNEC of 0.1 ng/L for EE2. For E2, fish were the most sensitive taxa, and chronic reproductive effects were the most sensitive endpoint. Using the SSD methodology, we derived a PNEC of 2 ng/L for E2. Insufficient data were available to construct an SSD for E1 or E3. Therefore, the authors used in vivo vitellogenin (VTG) induction studies to determine the relative potency of the steroid estrogens to induce VTG. Based on the relative differences between in vivo VTG induction, they derive PNECs of 6 and 60 ng/L for E1 and E3, respectively. Thus, for long-term exposures to steroid estrogens in surface water (i.e., >60 d), the PNECs are 6, 2, 60, and 0.1 ng/L for E1, E2, E3, and EE2, respectively. Higher PNECs are recommended for short-term (i.e., a few days or weeks) exposures. Environ. Toxicol. Chem. 2012;31:1396–1406. © 2012 SETAC
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kolpin, D. W., Furlong, E. T., Meyer, M. T., Thurman, E. M., Zaugg, S. D., Barber, L. B., & Buxton, H. T. (2002) · Environmental Science & Technology · doi:10.1021/es011055j · Cited by 7,953
Water Analysis: Emerging Contaminants and Current Issues
Richardson, S. D., & Ternes, T. A. (2014) · Analytical Chemistry · doi:10.1021/ac500508t · Cited by 2,144
Collapse of a fish population after exposure to a synthetic estrogen
Kidd, K. A., Blanchfield, P. J., Mills, K. H., Palace, V. P., Evans, R. E., Lazorchak, J. M., & Flick, R. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609568104 · Cited by 2,094
Routledge, E. J., & Sumpter, J. P. (1996) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620150303 · Cited by 1,504
Self-citationNash, J. P., Kime, D. E., Van der Ven, L. T. M., Wester, P. W., Brion, F., Maack, G., Stahlschmidt-Allner, P., & Tyler, C. R. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.7209 · Cited by 664
Länge, R., Hutchinson, T. H., Croudace, C. P., Siegmund, F., Schweinfurth, H., Hampe, P., Panter, G. H., & Sumpter, J. P. (2001) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620200610 · Cited by 649
Self-citationAlonso-Magdalena, P., Morimoto, S., Ripoll, C., Fuentes, E., & Nadal, A. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8451 · Cited by 632
Jobling, S., Williams, R., Johnson, A., Taylor, A., Gross-Sorokin, M., Nolan, M., Tyler, C. R., van Aerle, R., Santos, E., & Brighty, G. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8050 · Cited by 566
Metcalfe, C. D., Metcalfe, T. L., Kiparissis, Y., Koenig, B. G., Khan, C., Hughes, R. J., Croley, T. R., March, R. E., & Potter, T. (2001) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620200210 · Cited by 559
Mills, L. J., & Chichester, C. (2005) · Science of The Total Environment · doi:10.1016/j.scitotenv.2004.12.070 · Cited by 532
Relative Potencies and Combination Effects of Steroidal Estrogens in Fish
Thorpe, K. L., Cummings, R. I., Hutchinson, T. H., Scholze, M., Brighty, G., Sumpter, J. P., & Tyler, C. R. (2003) · Environmental Science & Technology · doi:10.1021/es0201348 · Cited by 514
Self-citationReproductive Disruption in Fish Downstream from an Estrogenic Wastewater Effluent
Vajda, A. M., Barber, L. B., Gray, J. L., Lopez, E. M., Woodling, J. D., & Norris, D. O. (2008) · Environmental Science & Technology · doi:10.1021/es0720661 · Cited by 466
Comparative responses of molluscs and fish to environmental estrogens and an estrogenic effluent
Jobling, S., Casey, D., Rodgers-Gray, T., Oehlmann, J., Schulte-Oehlmann, U., Pawlowski, S., Baunbeck, T., Turner, A. P., & Tyler, C. R. (2003) · Aquatic Toxicology · doi:10.1016/s0166-445x(03)00134-6 · Cited by 405
Accurate Prediction of the Response of Freshwater Fish to a Mixture of Estrogenic Chemicals
Brian, J. V., Harris, C. A., Scholze, M., Backhaus, T., Booy, P., Lamoree, M., Pojana, G., Jonkers, N., Runnalls, T., Bonfà, A., et al. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7598 · Cited by 393
Self-citationBrion, F., Tyler, C. R., Palazzi, X., Laillet, B., Porcher, J. M., Garric, J., & Flammarion, P. (2004) · Aquatic Toxicology · doi:10.1016/j.aquatox.2004.01.022 · Cited by 391
Water Analysis: Emerging Contaminants and Current Issues
Richardson, S. D., & Ternes, T. A. (2005) · Analytical Chemistry · doi:10.1021/ac058022x · Cited by 363
Parrott, J. L., & Blunt, B. R. (2005) · Environmental Toxicology · doi:10.1002/tox.20087 · Cited by 346
Hutchinson, T. H., Ankley, G. T., Segner, H., & Tyler, C. R. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8062 · Cited by 339
Panter, G. H., Thompson, R. S., & Sumpter, J. P. (1998) · Aquatic Toxicology · doi:10.1016/s0166-445x(98)00038-1 · Cited by 307
Self-citationVan den Belt, K., Berckmans, P., Vangenechten, C., Verheyen, R., & Witters, H. (2004) · Aquatic Toxicology · doi:10.1016/j.aquatox.2003.09.004 · Cited by 279
Caldwell, D. J., Mastrocco, F., Hutchinson, T. H., Länge, R., Heijerick, D., Janssen, C., Anderson, P. D., & Sumpter, J. P. (2008) · Environmental Science & Technology · doi:10.1021/es800633q · Cited by 265
Self-citationKramer, V. J., Miles-Richardson, S., Pierens, S. L., & Giesy, J. P. (1998) · Aquatic Toxicology · doi:10.1016/s0166-445x(97)00060-x · Cited by 249
Scholz, S. (2000) · Aquatic Toxicology · doi:10.1016/s0166-445x(00)00090-4 · Cited by 248
Pawlowski, S., van Aerle, R., Tyler, C. R., & Braunbeck, T. (2004) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2003.07.019 · Cited by 246
The Consequences of Feminization in Breeding Groups of Wild Fish
Harris, C. A., Hamilton, P. B., Runnalls, T. J., Vinciotti, V., Henshaw, A., Hodgson, D., Coe, T. S., Jobling, S., Tyler, C. R., & Sumpter, J. P. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1002555 · Cited by 225
Self-citationMiller, D. H., Jensen, K. M., Villeneuve, D. L., Kahl, M. D., Makynen, E. A., Durhan, E. J., & Ankley, G. T. (2007) · Environmental Toxicology and Chemistry · doi:10.1897/06-318r.1 · Cited by 214
Comparative responses of molluscs and fish to environmental estrogens and an estrogenic effluent
Jobling, S., Casey, D., Rodgers-Gray, T., Oehlmann, J., Schulte-Oehlmann, U., Pawlowski, S., Baunbeck, T., Turner, A. P., & Tyler, C. R. (2004) · Aquatic Toxicology · doi:10.1016/j.aquatox.2004.01.002 · Cited by 189
Shi, W., Wang, L., Rousseau, D. P. L., & Lens, P. N. L. (2010) · Environmental Science and Pollution Research · doi:10.1007/s11356-010-0301-7 · Cited by 181
Fenske, M., Maack, G., Schäfers, C., & Segner, H. (2005) · Environmental Toxicology and Chemistry · doi:10.1897/04-096r1.1 · Cited by 179
Schäfers, C., Teigeler, M., Wenzel, A., Maack, G., Fenske, M., & Segner, H. E. (2007) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390701236470 · Cited by 161
A national risk assessment for intersex in fish arising from steroid estrogens
Williams, R. J., Keller, V. D. J., Johnson, A. C., Young, A. R., Holmes, M. G. R., Wells, C., Gross, M. Y., & Benstead, R. (2008) · Environmental Toxicology and Chemistry · doi:10.1897/08-047.1 · Cited by 157
Balch, G. C., Mackenzie, C. A., & Metcalfe, C. D. (2004) · Environmental Toxicology and Chemistry · doi:10.1897/02-539 · Cited by 145
Xu, H. Y., Yang, J., Wang, Y., Qiu, J., Chen, H., & Song, H. (2008) · Aquatic Toxicology · doi:10.1016/j.aquatox.2008.01.020 · Cited by 144
Vitellogenin induction by 17β-estradiol and 17α-ethinylestradiol in male zebrafish (Danio rerio)
Rose, J., Holbech, H., Lindholst, C., et al. (2002) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/s1532-0456(02)00035-2 · Cited by 137
Zha, J., Sun, L., Zhou, Y., Spear, P. A., Ma, M., & Wang, Z. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.10.006 · Cited by 137
Soares, J., Coimbra, A. M., Reis-Henriques, M. A., Monteiro, N. M., Vieira, N., Oliveira, J. M. A., Guedes-Dias, P., Fontaínhas‐Fernandes, A., Parra, S., Carvalho, A. P., et al. (2009) · Aquatic Toxicology · doi:10.1016/j.aquatox.2009.07.021 · Cited by 129
Hintemann, T., Schneider, C., Schöler, H. F., & Schneider, R. J. (2006) · Water Research · doi:10.1016/j.watres.2006.04.028 · Cited by 126
Zillioux, E. J., Johnson, I. C., Kiparissis, Y., Metcalfe, C. D., Wheat, J. V., Ward, S. G., & Liu, H. (2001) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620200915 · Cited by 123
Schultz, I. R., Skillman, A. D., Nicolas, J.-M., Cyr, D. G., & Nagler, J. J. (2003) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620220613 · Cited by 120
Exposure assessment of 17α-ethinylestradiol in surface waters of the United States and Europe
Hannah, R. E., D’Aco, V. J., Anderson, P. D., Buzby, M. E., Caldwell, D. J., Cunningham, V. L., Ericson, J. F., Johnson, A. C., Parke, N. J., Samuelian, J. H., et al. (2009) · Environmental Toxicology and Chemistry · doi:10.1897/08-622.1 · Cited by 97
Self-citationvan der Ven, L. T. M., van den Brandhof, E., Vos, J. H., & Wester, P. W. (2006) · Environmental Toxicology and Chemistry · doi:10.1897/06-092r1.1 · Cited by 84
Kristensen, T. G., Baatrup, E., & Bayley, M. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.104.033001 · Cited by 84
Thorpe, K. L., Benstead, R., Hutchinson, T. H., & Tyler, C. R. (2007) · Aquatic Toxicology · doi:10.1016/j.aquatox.2007.08.012 · Cited by 80
Zha, J., Sun, L., Spear, P. A., & Wang, Z. (2008) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2007.11.017 · Cited by 65
Katsu, Y., Lange, A., Urushitani, H., Ichikawa, R., Paull, G. C., Cahill, L. L., Jobling, S., Tyler, C. R., & Iguchi, T. (2007) · Environmental Science & Technology · doi:10.1021/es062797l · Cited by 61
Coe, T. S., Söffker, M., Filby, A. L., Hodgson, D. J., & Tyler, C. R. (2010) · Environmental Science & Technology · doi:10.1021/es101185b · Cited by 57
Anderson, P. D., Johnson, A. C., Pfeiffer, D., Caldwell, D. J., Hannah, R. E., Mastrocco, F. J., Sumpter, J. P., & Williams, R. J. (2012) · Environmental Toxicology and Chemistry · doi:10.1002/etc.1824 · Cited by 54
Self-citationFilby, A. L., Shears, J. A., Drage, B. E., Churchley, J. H., & Tyler, C. R. (2010) · Environmental Science & Technology · doi:10.1021/es100602e · Cited by 52
Jukosky, J. A., Watzin, M. C., & Leiter, J. C. (2007) · Aquatic Toxicology · doi:10.1016/j.aquatox.2007.11.012 · Cited by 52
Toft, G. V., & Baatrup, E. (2003) · Ecotoxicology and Environmental Safety · doi:10.1016/s0147-6513(02)00138-0 · Cited by 45
Robinson, C. D., Brown, E. H., Craft, J. A., Davies, I. M., Megginson, C., Miller, C., & Moffat, C. F. (2007) · Aquatic Toxicology · doi:10.1016/j.aquatox.2006.12.020 · Cited by 38
Cripe, G. M., Hemmer, B. L., Goodman, L. R., Fournie, J. W., Raimondo, S., Vennari, J., Danner, R. L., Smith, K., Manfredonia, B. R., Kulaw, D. H., et al. (2009) · Environmental Toxicology and Chemistry · doi:10.1897/08-542.1 · Cited by 37
Sowers, A., Gaworecki, K. M., Mills, M., Roberts, A., & Klaine, S. (2009) · Aquatic Toxicology · doi:10.1016/j.aquatox.2009.08.012 · Cited by 29
Shappell, N. W., Elder, K. H., & West, M. A. (2010) · Environmental Science & Technology · doi:10.1021/es903669m · Cited by 26
Cited by
Pharmaceuticals in the environment-global occurrences and perspectives
aus der Beek, T., Weber, F.-A., Bergmann, A., Hickmann, S., Ebert, I., Hein, A., & Küster, A. (2015) · Environmental Toxicology and Chemistry · doi:10.1002/etc.3339 · Cited by 1,595
Fekadu, S., Alemayehu, E., Dewil, R., & Van der Bruggen, B. (2019) · Science of The Total Environment · doi:10.1016/j.scitotenv.2018.11.072 · Cited by 499
Medicating the environment: assessing risks of pharmaceuticals to wildlife and ecosystems
Arnold, K. E., Brown, A. R., Ankley, G. T., & Sumpter, J. P. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0569 · Cited by 441
Self-citationDirect and Indirect Responses of a Freshwater Food Web to a Potent Synthetic Oestrogen
Kidd, K. A., Paterson, M. J., Rennie, M. D., Podemski, C. L., Findlay, D. L., Blanchfield, P. J., & Liber, K. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0578 · Cited by 189
Metadata
- Authors
- Caldwell, D. J., Mastrocco, F., Anderson, P. D., Länge, R., & Sumpter, J. P.
- Venue
- Environmental Toxicology and Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-04-05
- Volume
- 31
- Issue
- 6
- Pages
- 1396-1406
- ISSN
- 0730-7268 (ISSN-L)
- 1552-8618
- OpenAlex
- W2069157996
- Cited by
- 373
- References
- 54
- FWCI
- 17.59
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.