The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Genetic alterations in breast cancer
Abstract
The etiology of breast cancer involves a complex interplay of various factors, including genetic alterations. Many studies have been devoted to the identification and characterization of mutations that occur frequently during breast tumorigenesis. The major types of genetic abnormalities that are frequently observed in breast tumors are amplification of protooncogenes (MYC, ERBB2) and DNA from chromosome band 11q13; mutation of TP53; and loss of heterozygosity from chromosomes and chromosome arms 1, 3p, 6q, 7q, 8p, 11, 13q, 16q, 17, 18q, and 22q. The latter may correspond to losses or inactivations of tumor suppressor genes. Recently, linkage analyses of large families with a predisposition to breast cancer have been performed in order to map breast cancer susceptibility genes (TP53, BRCA1, BRCA2). The findings have thrown light on the molecular mechanisms of breast cancer and have enabled various genetic markers to be used in clinical oncology.
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Cites
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Genetic alterations in bladder cancer
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Cited by
Gene expression profiling predicts clinical outcome of breast cancer
van 't Veer, L. J., Dai, H., van de Vijver, M. J., He, Y. D., Hart, A. A. M., Mao, M., Peterse, H. L., van der Kooy, K., Marton, M. J., Witteveen, A. T., et al. (2002) · Nature · doi:10.1038/415530a · Cited by 9,536
Epidermal growth factor receptor: Mechanisms of activation and signalling
Jorissen, R. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00098-8 · Cited by 1,565
Specific protection against breast cancers by cyclin D1 ablation
Yu, Q., Geng, Y., & Sicinski, P. (2001) · Nature · doi:10.1038/35082500 · Cited by 934
Requirement for CDK4 kinase function in breast cancer
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Telomerase activity in ductal carcinoma in situ of the breast
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Metadata
- Authors
- Bièche, I., & Lidereau, R.
- Venue
- Genes, Chromosomes and Cancer
- Publisher
- Wiley
- Published
- 1995-12
- Volume
- 14
- Issue
- 4
- Pages
- 227-251
- ISSN
- 1045-2257 (ISSN-L)
- 1098-2264
- OpenAlex
- W2025047211
- Cited by
- 303
- References
- 9
- FWCI
- 12.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bièche, I., & Lidereau, R. (1995). Genetic alterations in breast cancer. Genes, Chromosomes and Cancer. https://doi.org/10.1002/gcc.2870140402
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
