Cited by 1,565HER2/EGFR in Cancer ResearchReceptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Epidermal growth factor receptor: Mechanisms of activation and signalling

Jorissen, R·2003·Experimental Cell Research

Abstract

The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-alpha, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes.

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Crossref · 10.1016/s0014-4827(02)00098-8

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291 of 291 references verified0 citation errors · 0 not checkable

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Authors
Jorissen, R.
Affiliations
The Royal Melbourne Hospital (AU)
Corresponding author
Jorissen, R
Venue
Experimental Cell Research
Publisher
Elsevier BV
Published
2003-03-10
Volume
284
Issue
1
Pages
31-53
ISSN
0014-4827 (ISSN-L)
OpenAlex
W2043911313
Cited by
1,565
References
291
Citations by year
2026: 10 · 2025: 28 · 2024: 41 · 2023: 50 · 2022: 36 · 2021: 37 · 2020: 68 · 2019: 42 · 2018: 41 · 2017: 61 · 2016: 67 · 2015: 75 · 2014: 85 · 2013: 84 · 2012: 95
FWCI
41.66
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental Cell Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
epidermal growth factor receptor, EGFR activation, receptor signaling, ligand binding, transforming growth factor-alpha, neuregulin, receptor tyrosine kinase, crystal structure, growth factor receptors
MeSH terms
Animals, Cell Movement, Humans, Models, Molecular, Protein Conformation, Transforming Growth Factors, Signal Transduction, ErbB Receptors

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