The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
hGFAP‐cre transgenic mice for manipulation of glial and neuronal function in vivo
Abstract
With the goal of performing astrocyte‐specific modification of genes in the mouse, we have generated a transgenic line expressing Cre recombinase under the control of the human glial fibrillary acidic protein (hGFAP) promoter. Activity was monitored by crossing the hGFAP‐cre transgenics with either of two reporter lines carrying a lacZ gene whose expression requires excision of loxP‐flanked stop sequences. We found that lacZ expression was primarily limited to the central nervous system, but therein was widespread in neurons and ependyma. Cell types within the brain that notably failed to activate lacZ expression included Purkinje neurons of the cerebellum and choroid plexus epithelium. Onset of Cre expression began in the forebrain by e13.5, suggesting that the hGFAP promoter is active in a multi‐potential neural stem cell. genesis 31:85–94, 2001. © 2001 Wiley‐Liss, Inc.
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“Subsequent breeding of the Cre transgenics with mice carrying an allele containing a critical region flanked by loxP sites results in excision of the floxed sequence specifically in the cells expressing the Cre transgene (Gu et al., 1994; Kühn et al., 1995; Tsien et al., 1996).”
BackgroundIsolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage
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Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Molecular dissection of reactive astrogliosis and glial scar formation
Sofroniew, M. V. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.08.002 · Cited by 2,594
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Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.09.015 · Cited by 2,027
Mederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications · doi:10.1038/ncomms3823 · Cited by 1,443
Middeldorp, J., & Hol, E. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.005 · Cited by 1,080
Metadata
- Authors
- Zhuo, L., Theis, M., Alvarez‐Maya, I., Brenner, M., Willecke, K., & Messing, A.
- Venue
- genesis
- Publisher
- Wiley
- Published
- 2001-10
- Volume
- 31
- Issue
- 2
- Pages
- 85-94
- ISSN
- 1526-954X (ISSN-L)
- 1526-968X
- OpenAlex
- W2053726612
- Cited by
- 659
- References
- 7
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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