The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Inducible site‐specific recombination in myelinating cells
Abstract
Summary: To explore the function of genes expressed by myelinating cells we have developed a model system that allows for the inducible ablation of predetermined genes in oligodendrocytes and Schwann cells. The Cre/loxP recombination system provides the opportunity to generate tissue‐specific somatic mutations in mice. We have used a fusion protein between the Cre recombinase and a mutated ligand‐binding domain of the human estrogen receptor (CreER T) to obtain inducible, site‐specific recombination. CreER T expression was placed under the transcriptional control of the regulatory sequences of the myelin proteolipid protein (PLP) gene, which is abundantly expressed in oligodendrocytes and to a lesser extent in Schwann cells. The CreER T fusion protein translocated to the nucleus and mediated the recombination of a LacZ reporter transgene in myelinating cells of PLP/CreER T mice injected with the synthetic steroid tamoxifen. In untreated animals CreER T remained cytoplasmic, and there was no evidence of recombination. The PLP/ CreER T animals should be very useful in elucidating and distinguishing a particular gene's function in the formation and maintenance of the myelin sheath and in analyzing mature oligodendrocyte function in pathological conditions. genesis 35:63–72, 2003. © 2002 Wiley‐Liss, Inc.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
Baumann, N., & Pham-Dinh, D. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.871 · Cited by 1,828
Inducible Gene Targeting in Mice
Kühn, R., Schwenk, F., Aguet, M., & Rajewsky, K. (1995) · Science · doi:10.1126/science.7660125 · Cited by 1,641
Basic Neurochemistry???Molecular, Cellular, and Medical Aspects
Long, D. M. (2006) · Neurosurgery Quarterly · doi:10.1097/01.wnq.0000203279.82150.41 · Cited by 1,284
Cre recombinase: The universal reagent for genome tailoring
Nagy, A. (2000) · genesis · doi:10.1002/(sici)1526-968x(200002)26:2<99::aid-gene1>3.0.co;2-b · Cited by 1,265
Ligand-activated site-specific recombination in mice.
Feil, R., Brocard, J., Mascrez, B., LeMeur, M., Metzger, D., & Chambon, P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.10887 · Cited by 907
Metzger, D., Clifford, J., Chiba, H., & Chambon, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6991 · Cited by 570 · cited 1×
“Steroid hormone receptors have been exploited to confer temporal control to the Cre recombinase (Metzger et al., 1995; Kellendonk et al., 1996).”
BackgroundMallon, B. S., Shick, H. E., Kidd, G. J., & Macklin, W. B. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00876.2002 · Cited by 382
Self-citationMyelin synthesis in the peripheral nervous system
Garbay, B. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00049-0 · Cited by 314
Multiple restricted origin of oligodendrocytes
Spassky, N., Goujet-Zalc, C., Parmantier, E., Olivier, C., Martinez, S., Ikenaka, K., Macklin, W., Zalc, B., & Thomas, J.-L. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)91253-x · Cited by 301
Self-citationMyelin Formation, Structure and Biochemistry
Morell, P., & Quarles, R. H. (1999) · Cited by 290
Cited by
Oligodendroglia metabolically support axons and contribute to neurodegeneration
Lee, Y., Morrison, B. M., Li, Y., Lengacher, S., Farah, M. H., Hoffman, P. N., Liu, Y., Tsingalia, A., Jin, L., Zhang, P.-W., et al. (2012) · Nature · doi:10.1038/nature11314 · Cited by 1,664
A critical period for social experience-dependent oligodendrocyte maturation and myelination
Makinodan, M., Rosen, K. M., Ito, S., & Corfas, G. (2012) · Science · doi:10.1126/science.1220845 · Cited by 922
Kang, S. H., Fukaya, M., Yang, J. K., Rothstein, J. D., & Bergles, D. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.009 · Cited by 787
Kang, S. H., Li, Y., Fukaya, M., Lorenzini, I., Cleveland, D. W., Ostrow, L. W., Rothstein, J. D., & Bergles, D. E. (2013) · Nature Neuroscience · doi:10.1038/nn.3357 · Cited by 599
Skelly, D. A., Squiers, G. T., McLellan, M. A., Bolisetty, M. T., Robson, P., Rosenthal, N. A., & Pinto, A. R. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.072 · Cited by 560
Metadata
- Authors
- Doerflinger, N. H., Macklin, W. B., & Popko, B.
- Venue
- genesis
- Publisher
- Wiley
- Published
- 2002-12-09
- Volume
- 35
- Issue
- 1
- Pages
- 63-72
- ISSN
- 1526-954X (ISSN-L)
- 1526-968X
- OpenAlex
- W2146882075
- Cited by
- 300
- References
- 32
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Inducible site‐specific recombination in myelinating cells. https://app.cochat.ai/papers/10.1002/gene.10154
- The paper
- Doerflinger, N. H., Macklin, W. B., & Popko, B. (2003). Inducible site‐specific recombination in myelinating cells. genesis. https://doi.org/10.1002/gene.10154
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
