The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart
Open accessAbstract
Characterization of the cardiac cellulome, the network of cells that form the heart, is essential for understanding cardiac development and normal organ function and for formulating precise therapeutic strategies to combat heart disease. Recent studies have reshaped our understanding of cardiac cellular composition and highlighted important functional roles for non-myocyte cell types. In this study, we characterized single-cell transcriptional profiles of the murine non-myocyte cardiac cellular landscape using single-cell RNA sequencing (scRNA-seq). Detailed molecular analyses revealed the diversity of the cardiac cellulome and facilitated the development of techniques to isolate understudied cardiac cell populations, such as mural cells and glia. Our analyses also revealed extensive networks of intercellular communication and suggested prevalent sexual dimorphism in gene expression in the heart. This study offers insights into the structure and function of the mammalian cardiac cellulome and provides an important resource that will stimulate studies in cardiac cell biology.
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Cites
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InfluentialIntegrating single-cell transcriptomic data across different conditions, technologies, and species
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Cited by
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Deciphering cell–cell interactions and communication from gene expression
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Transcriptional and Cellular Diversity of the Human Heart
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Metadata
- Authors
- Skelly, D. A., Squiers, G. T., McLellan, M. A., Bolisetty, M. T., Robson, P., Rosenthal, N. A., & Pinto, A. R.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 22
- Issue
- 3
- Pages
- 600-610
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2783252067
- Cited by
- 560
- References
- 59
- FWCI
- 20.33
- Type
- journal article
- Language
- en
- Open access
- gold
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- Skelly, D. A., Squiers, G. T., McLellan, M. A., Bolisetty, M. T., Robson, P., Rosenthal, N. A., & Pinto, A. R. (2018). Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart. Cell Reports. https://doi.org/10.1016/j.celrep.2017.12.072
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
