The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
DNA methylation variation in cloned mice
Abstract
Summary: Mammalian cloning has been accomplished in several mammalian species by nuclear transfer. However, the production rate of cloned animals is quite low, and many cloned offspring die or show abnormal symptoms. A possible cause of the low success rate of cloning and abnormal symptoms in many cloned animals is the incomplete reestablishment of DNA methylation after nuclear transfer. We first analyzed tissue‐specific methylation patterns in the placenta, skin, and kidney of normal B6D2F1 mice. There were seven spots/CpG islands (0.5% of the total CpG islands detected) methylated differently in the three different tissues examined. In the placenta and skin of two cloned fetuses, a total of four CpG islands were aberrantly methylated or unmethylated. Interestingly, three of these four loci corresponded to the tissue‐specific loci in the normal control fetuses. The extent of aberrant methylation of genomic DNA varied between the cloned animals. In cloned animals, aberrant methylation occurred mainly at tissue‐specific methylated loci. Individual cloned animals have different methylation aberrations. In other words, cloned animals are by no means perfect copies of the original animals as far as the methylation status of genomic DNA is concerned. genesis 30:45–50, 2001. © 2001 Wiley‐Liss, Inc.
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Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Extension of Cell Life-Span and Telomere Length in Animals Cloned from Senescent Somatic Cells
Lanza, R. P., Cibelli, J. B., Blackwell, C., Cristofalo, V. J., Francis, M. K., Baerlocher, G. M., Mak, J., Schertzer, M., Chavez, E. A., Sawyer, N., et al. (2000) · Science · doi:10.1126/science.288.5466.665 · Cited by 466
Cited by
Delayed and incomplete reprogramming of chromosome methylation patterns in bovine cloned embryos
Bourc'his, D., Le Bourhis, D., Patin, D., Niveleau, A., Comizzoli, P., Renard, J.-P., & Viegas-Péquignot, E. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00480-8 · Cited by 393
Cloned mice have an obese phenotype not transmitted to their offspring
Tamashiro, K. L. K., Wakayama, T., Akutsu, H., Yamazaki, Y., Lachey, J. L., Wortman, M. D., Seeley, R. J., D'Alessio, D. A., Woods, S. C., Yanagimachi, R., et al. (2002) · Nature Medicine · doi:10.1038/nm0302-262 · Cited by 356
Self-citationEmbryonic stem cells and somatic cells differ in mutation frequency and type
Cervantes, R. B., Stringer, J. R., Shao, C., Tischfield, J. A., & Stambrook, P. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062527199 · Cited by 317
Metadata
- Authors
- Ohgane, J., Wakayama, T., Kogo, Y., Senda, S., Hattori, N., Tanaka, S., Yanagimachi, R., & Shiota, K.
- Venue
- genesis
- Publisher
- Wiley
- Published
- 2001-06
- Volume
- 30
- Issue
- 2
- Pages
- 45-50
- ISSN
- 1526-954X (ISSN-L)
- 1526-968X
- OpenAlex
- W2166002518
- Cited by
- 219
- References
- 3
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ohgane, J., Wakayama, T., Kogo, Y., Senda, S., Hattori, N., Tanaka, S., Yanagimachi, R., & Shiota, K. (2001). DNA methylation variation in cloned mice. genesis. https://doi.org/10.1002/gene.1031
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