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Cited by 115Lipoproteins and Cardiovascular HealthGenetic Associations and EpidemiologyParaoxonase enzyme and polymorphisms

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Apo E allele frequencies in younger (age 42–50) vs older (age 65–90) women

Cauley, Jane A., Eichner, June E., Ilyas Kamboh, M., Ferrell, Robert E., Kuller, Lewis H.·1993·Genetic Epidemiology
DOI 10.1002/gepi.1370100104
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Abstract

Allelic variation at the apolipoprotien E (Apo E) structural locus has been shown to influence concentrations of total cholesterol and low density lipoprotein cholesterol (LDL‐C). Apo E has six phenotypes resulting from three common alleles at this locus. The ϵ2 allele is associated with lower LDL‐C and the ϵ4 allele with higher LDL‐C. In the current study, we compared the ϵ allele distribution in two cohorts of white women recruited from population based listing of southwestern Pennsylvania. The “younger” cohort consisted of 473 women, age 42–50; the “older” cohort, 870 women, age 65–90. A comparison of the overall distribution of allele frequencies in the two cohorts was significantly different. The allele frequency of ϵ4 was lower in the older cohort (0.98 vs. 0.122, P = 1.08) and the ϵ2 allele frequency was higher (0.084 vs. 0.059, P = 0.05) in the older cohort. These observations are consistent with the hypothesis that there may be a selection against individuals with the ϵ4 allele. However, future research is needed to confirm this observation and to compare survival in individuals by their ϵ allele. © 1993 Wiley‐Liss. Inc.

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Research works printed but not linked: 3

  1. 10.1001/jama.1990.03440050059033 · DOI
  2. Davignon J, 1988, Apolipoprotein E polymorphism and atherosclerosis: insight from a study in octogenarians. Transact, Am Clin Climatol Assoc, 99, 100
  3. Warnick GR, 1987, A comprehensive evluation of the heparin manganese precipitation procedure for estimating high density lipoprotein cholesterol, J Lipid Res, 29, 65

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Metadata

Authors
Cauley, J. A., Eichner, J. E., Ilyas Kamboh, M., Ferrell, R. E., & Kuller, L. H.
Affiliations
University of Pittsburgh (US)
Corresponding author
Cauley, Jane A.
ORCID
Venue
Genetic Epidemiology
Publisher
Wiley
Published
1993-01
Volume
10
Issue
1
Pages
27-34
ISSN
  • 0741-0395 (ISSN-L)
  • 1098-2272
DOI
10.1002/gepi.1370100104
OpenAlex
W1919970019
Cited by
115
References
26
Citations by year
2026: 2 · 2024: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 2
FWCI
17.58
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4536 d)
Locations
  • Genetic Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29hl040489-05)
  • National Institute on Aging
  • National Heart, Lung, and Blood Institute (HL-40489, HL-28266, R01HL028266)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 35582, R01AR035582)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords
apolipoprotein E, allele frequency, age differences, older women, LDL cholesterol, genetic selection, APOE ε4, APOE2, white women
MeSH terms
Aged, Aging, Apolipoproteins E, Cholesterol, Female, Gene Frequency, Humans, Middle Aged, Phenotype

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