Cited by 115Lipoproteins and Cardiovascular HealthGenetic Associations and EpidemiologyParaoxonase enzyme and polymorphisms

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Apo E allele frequencies in younger (age 42–50) vs older (age 65–90) women

Cauley, Jane A., Eichner, June E., Ilyas Kamboh, M., Ferrell, Robert E., Kuller, Lewis H.·1993·Genetic Epidemiology

DOI 10.1002/gepi.1370100104

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Abstract

Allelic variation at the apolipoprotien E (Apo E) structural locus has been shown to influence concentrations of total cholesterol and low density lipoprotein cholesterol (LDL‐C). Apo E has six phenotypes resulting from three common alleles at this locus. The ϵ2 allele is associated with lower LDL‐C and the ϵ4 allele with higher LDL‐C. In the current study, we compared the ϵ allele distribution in two cohorts of white women recruited from population based listing of southwestern Pennsylvania. The “younger” cohort consisted of 473 women, age 42–50; the “older” cohort, 870 women, age 65–90. A comparison of the overall distribution of allele frequencies in the two cohorts was significantly different. The allele frequency of ϵ4 was lower in the older cohort (0.98 vs. 0.122, P = 1.08) and the ϵ2 allele frequency was higher (0.084 vs. 0.059, P = 0.05) in the older cohort. These observations are consistent with the hypothesis that there may be a selection against individuals with the ϵ4 allele. However, future research is needed to confirm this observation and to compare survival in individuals by their ϵ allele. © 1993 Wiley‐Liss. Inc.

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Authors: Cauley, J. A., Eichner, J. E., Ilyas Kamboh, M., Ferrell, R. E., & Kuller, L. H.
Affiliations: University of Pittsburgh (US)
Corresponding author: Cauley, Jane A.
ORCID: Cauley, Jane A.
Kuller, Lewis H.
Venue: Genetic Epidemiology
Publisher: Wiley
Published: 1993-01
Volume: 10
Issue: 1
Pages: 27-34
ISSN: 0741-0395 (ISSN-L)
1098-2272
DOI: 10.1002/gepi.1370100104
OpenAlex: W1919970019
Cited by: 115
References: 26
Citations by year: 2026: 2 · 2024: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 2
FWCI: 17.58
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4536 d)
Locations: Genetic Epidemiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r29hl040489-05)
National Institute on Aging
National Heart, Lung, and Blood Institute (HL-40489, HL-28266, R01HL028266)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 35582, R01AR035582)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: apolipoprotein E, allele frequency, age differences, older women, LDL cholesterol, genetic selection, APOE ε4, APOE2, white women
MeSH terms: Aged, Aging, Apolipoproteins E, Cholesterol, Female, Gene Frequency, Humans, Middle Aged, Phenotype

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Apo E allele frequencies in younger (age 42–50) vs older (age 65–90) women

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